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Allen A. Thomas, Ph.D.

Affiliations:	2000		Scripps Research Institute, La Jolla, La Jolla, CA, United States
	2000-2013		Array Biopharma, Inc.
	2014-	Chemistry	University of Nebraska at Kearney, Kearney, NE, United States

Area:

Medicinal Chemistry

Website:

https://thomasresearch.net/

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Mean distance: 7.73

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Parents

K. Barry Sharpless	grad student	2000	Scripps Institute
(I. Aminohydroxylation of unsaturated phosphonates: A template for molecular diversity. II. Rapid discoveries in osmium (VIII) catalysis using automation and mass spectrometry.)

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Publications

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Hall C, Wolfe H, Wells A, et al. (2019) l-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of l-histidine and l-tryptophan. Bioorganic & Medicinal Chemistry Letters
Chien HC, Colas C, Finke K, et al. (2018) Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1). Journal of Medicinal Chemistry
Zur AA, Chien HC, Augustyn E, et al. (2016) LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates. Bioorganic & Medicinal Chemistry Letters
Augustyn E, Finke K, Zur AA, et al. (2016) LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs. Bioorganic & Medicinal Chemistry Letters
Thomas AA, Hunt KW, Volgraf M, et al. (2014) Discovery of 7-tetrahydropyran-2-yl chromans: Î²-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid Î²-protein (AÎ²) in the central nervous system. Journal of Medicinal Chemistry. 57: 878-902
Dupau P, Epple R, Thomas AA, et al. (2010) ChemInform Abstract: Osmium-Catalyzed Dihydroxylation of Olefins in Acidic Media: Old Process, New Tricks. Cheminform. 33: no-no
Thomas AA, Le Huerou Y, De Meese J, et al. (2008) Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 2206-10
Le Huerou Y, Gunawardana I, Thomas AA, et al. (2008) Prodrug thiamine analogs as inhibitors of the enzyme transketolase. Bioorganic & Medicinal Chemistry Letters. 18: 505-8
Dupau P, Epple R, Thomas AA, et al. (2002) Osmium-Catalyzed Dihydroxylation of Olefins in Acidic Media: Old Process, New Tricks Advanced Synthesis and Catalysis. 344: 421-433
Thomas AA, Sharpless KB. (1999) The Catalytic Asymmetric Aminohydroxylation of Unsaturated Phosphonates. The Journal of Organic Chemistry. 64: 8379-8385

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