Marian C. Bryan, Ph.D.

Affiliations: 
2004 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
organic chemistry
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"Marian Bryan"
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Chi-Huey Wong grad student 2004 Scripps Institute
 (Development and application of glycoarray strategies.)
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Publications

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Chan BK, Hanan EJ, Bowman K, et al. (2016) Discovery of a Non-Covalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor. Journal of Medicinal Chemistry
Bryan MC, Burdick DJ, Chan BK, et al. (2016) Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR. Acs Medicinal Chemistry Letters. 7: 100-4
Hanan EJ, Baumgardner M, Bryan MC, et al. (2015) 4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase. Bioorganic & Medicinal Chemistry Letters
Heald RA, Chan BK, Bryan 2C, et al. (2015) Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case History. Journal of Medicinal Chemistry
Epstein O, Bryan MC, Cheng AC, et al. (2014) Lead optimization and modulation of hERG activity in a series of aminooxazoline xanthene β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors. Journal of Medicinal Chemistry. 57: 9796-810
Hanan EJ, Eigenbrot C, Bryan MC, et al. (2014) Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation. Journal of Medicinal Chemistry. 57: 10176-91
Bryan MC, Hein CD, Gao H, et al. (2013) Disubstituted 1-aryl-4-aminopiperidine library synthesis using computational drug design and high-throughput batch and flow technologies. Acs Combinatorial Science. 15: 503-11
Bryan MC, Dillon B, Hamann LG, et al. (2013) Sustainable practices in medicinal chemistry: current state and future directions. Journal of Medicinal Chemistry. 56: 6007-21
Bryan MC, Falsey JR, Frohn M, et al. (2013) N-substituted azaindoles as potent inhibitors of Cdc7 kinase. Bioorganic & Medicinal Chemistry Letters. 23: 2056-60
Eschelbach JW, Wernick D, Bryan MC, et al. (2013) Characterization of dispersion effects on reaction optimization and scale-up for a packed bed flow hydrogenation reactor Australian Journal of Chemistry. 66: 165-171
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