Joey-Lee Methot, Ph.D.

Affiliations: 
2002 University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Chemical Biology
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"Joey-Lee Methot"
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Peter Wipf grad student 2002 University of Pittsburgh
 (Studies in natural product synthesis: Aeruginosin 298-A and diazonamide A.)
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Publications

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Fradera X, Deng Q, Achab A, et al. (2021) Discovery of a new series of PI3K-δ inhibitors from Virtual Screening. Bioorganic & Medicinal Chemistry Letters. 128046
Vara BA, Levi SM, Achab A, et al. (2021) Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds. Acs Medicinal Chemistry Letters. 12: 653-661
Methot JL, Zhou H, McGowan MA, et al. (2021) Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators. Journal of Medicinal Chemistry
Yu EC, Methot JL, Fradera X, et al. (2021) Identification of Potent Reverse Indazole Inhibitors for HPK1. Acs Medicinal Chemistry Letters. 12: 459-466
Methot JL, Achab A, Christopher M, et al. (2020) Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors. Acs Medicinal Chemistry Letters. 11: 2461-2469
Wang Y, Zhang K, Georgiev P, et al. (2020) Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function. Plos One. 15: e0243145
Lacey BM, Xu Z, Chai X, et al. (2020) Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors. Slas Discovery : Advancing Life Sciences R & D. 2472555220952071
Fradera X, Methot JL, Achab A, et al. (2020) Corrigendum to "Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow" [Bioorg. Med. Chem. Lett. 29 (2019) 2575-2580]. Bioorganic & Medicinal Chemistry Letters. 127363
Zhou H, McGowan MA, Lipford K, et al. (2019) Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors. Bioorganic & Medicinal Chemistry Letters. 126715
Fradera X, Methot JL, Achab A, et al. (2019) Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow. Bioorganic & Medicinal Chemistry Letters
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