Alec D. Lebsack, Ph.D.

2002 University of California, Irvine, Irvine, CA 
synthesis of natural products
"Alec Lebsack"
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Larry E. Overman grad student 2002 UC Irvine
 (Enantioselective total synthesis of shahamin K and enantioselective total synthesis of quadrigemine C and psycholeine.)
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Rech JC, Bhattacharya A, Branstetter BJ, et al. (2016) The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists. Bioorganic & Medicinal Chemistry Letters
Blevitt JM, Hack MD, Herman K, et al. (2016) A Single Amino Acid Difference between Mouse and Human 5-lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors. The Journal of Biological Chemistry
Song J, Liu X, Zhu J, et al. (2015) Polypharmacology of Small-Molecule Modulators of the 5-Lipoxygenase Activating Protein (FLAP) Observed via a High-throughput Lipidomics Platform. Journal of Biomolecular Screening
Canham SM, Hafensteiner BD, Lebsack AD, et al. (2015) Stereocontrolled enantioselective total synthesis of the [2+2] quadrigemine alkaloids. Tetrahedron. 71: 6424-6436
Canham SM, Hafensteiner BD, Lebsack AD, et al. (2015) Stereocontrolled enantioselective total synthesis of the [2+2] quadrigemine alkaloids Tetrahedron
Maher MP, Bhattacharya A, Ao H, et al. (2011) Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist. European Journal of Pharmacology. 663: 40-50
Liu J, Fitzgerald AE, Lebsack AD, et al. (2011) Scale-up synthesis of a TRPV1 antagonist featuring a facile thiazolo[5,4-d]pyrimidine formation Organic Process Research and Development. 15: 382-388
Hawryluk NA, Merit JE, Lebsack AD, et al. (2010) Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. 20: 7137-41
Lebsack AD, Rech JC, Branstetter BJ, et al. (2010) 1,2-diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines as TRPV1 antagonists with improved properties. Bioorganic & Medicinal Chemistry Letters. 20: 7142-6
Venkatraman S, Lebsack AD, Alves K, et al. (2009) Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist. Bioorganic & Medicinal Chemistry Letters. 19: 5803-6
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