Thomas M. Razler, Ph.D.

Affiliations: 
2006 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Natural product synthesis
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Amos B. Smith, III grad student 2006 Penn
 (Synthetic and biological studies of (+)-phorboxazole A: Second-generation total synthesis of (+)-phorboxazole A. Synthesis and biological evaluation of phorboxazole analogues. Progress toward the gram-scale synthesis of (+)-chlorophorboxazole A.)
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Conlon DA, Natalie KJ, Cuniere N, et al. (2016) Development of a Practical Synthesis of Functionalized Azaxanthene-Derived Nonsteroidal Glucocorticoid Receptor Modulators Organic Process Research and Development. 20: 921-933
Ji Y, Plata RE, Regens CS, et al. (2015) Mono-Oxidation of Bidentate Bis-phosphines in Catalyst Activation: Kinetic and Mechanistic Studies of a Pd/Xantphos-Catalyzed C-H Functionalization. Journal of the American Chemical Society. 137: 13272-81
Hartley RF, Huang Y, Cassidy M, et al. (2012) Degradation kinetics and mechanism of an oxadiazole derivative, design of a stable drug product for BMS-708163, a γ-secretase inhibitor drug candidate. Journal of Pharmaceutical Sciences. 101: 3124-33
Smith AB, Hogan AM, Liu Z, et al. (2011) Phorboxazole Synthetic Studies: Design, Synthesis and Biological Evaluation of Phorboxazole A and Hemi-Phorboxazole A Related Analogues. Tetrahedron. 67: 5069-5078
Zhu J, Razler TM, Xu Z, et al. (2011) A robust three-step telescoped synthesis of electron-deficient amide substituted arylboronic acids Organic Process Research and Development. 15: 438-442
Razler TM, Hsiao Y, Qian F, et al. (2009) A preparatively convenient ligand-free catalytic PEG 2000 Suzuki-Miyaura coupling. The Journal of Organic Chemistry. 74: 1381-4
Smith AB, Fox RJ, Razler TM. (2008) Evolution of the Petasis-Ferrier union/rearrangement tactic: construction of architecturally complex natural products possessing the ubiquitous cis-2,6-substituted tetrahydropyran structural element. Accounts of Chemical Research. 41: 675-87
Smith AB, Razler TM, Meis RM, et al. (2008) Synthesis and biological evaluation of phorboxazole congeners leading to the discovery and preparative-scale synthesis of (+)-chlorophorboxazole a possessing picomolar human solid tumor cell growth inhibitory activity. The Journal of Organic Chemistry. 73: 1201-8
Smith AB, Razler TM, Ciavarri JP, et al. (2008) A second-generation total synthesis of (+)-phorboxazole A. The Journal of Organic Chemistry. 73: 1192-200
Bullington J, Argentieri D, Averill K, et al. (2006) Inhibitors of unactivated p38 MAP kinase. Bioorganic & Medicinal Chemistry Letters. 16: 6102-6
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