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Thomas M. Razler, Ph.D.

Affiliations: 
2006 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Natural product synthesis
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"Thomas Razler"
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Amos B. Smith, III grad student 2006 Penn
 (Synthetic and biological studies of (+)-phorboxazole A: Second-generation total synthesis of (+)-phorboxazole A. Synthesis and biological evaluation of phorboxazole analogues. Progress toward the gram-scale synthesis of (+)-chlorophorboxazole A.)

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Beutner G, Carrasquillo R, Geng P, et al. (2018) Adventures in Atropisomerism: Total Synthesis of a Complex Active Pharmaceutical Ingredient with Two Chirality Axes. Organic Letters
Beutner GL, Hsiao Y, Razler T, et al. (2017) Nickel-Catalyzed Synthesis of Quinazolinediones. Organic Letters. 19: 1052-1055
Conlon DA, Natalie KJ, Cuniere N, et al. (2016) Development of a Practical Synthesis of Functionalized Azaxanthene-Derived Nonsteroidal Glucocorticoid Receptor Modulators Organic Process Research and Development. 20: 921-933
Smith AB, Hogan AM, Liu Z, et al. (2011) Phorboxazole Synthetic Studies: Design, Synthesis and Biological Evaluation of Phorboxazole A and Hemi-Phorboxazole A Related Analogues. Tetrahedron. 67: 5069-5078
Zhu J, Razler TM, Xu Z, et al. (2011) A robust three-step telescoped synthesis of electron-deficient amide substituted arylboronic acids Organic Process Research and Development. 15: 438-442
Smith AB, Fox RJ, Razler TM. (2008) Evolution of the Petasis-Ferrier union/rearrangement tactic: construction of architecturally complex natural products possessing the ubiquitous cis-2,6-substituted tetrahydropyran structural element. Accounts of Chemical Research. 41: 675-87
Smith AB, Razler TM, Meis RM, et al. (2008) Synthesis and biological evaluation of phorboxazole congeners leading to the discovery and preparative-scale synthesis of (+)-chlorophorboxazole a possessing picomolar human solid tumor cell growth inhibitory activity. The Journal of Organic Chemistry. 73: 1201-8
Smith AB, Razler TM, Ciavarri JP, et al. (2008) A second-generation total synthesis of (+)-phorboxazole A. The Journal of Organic Chemistry. 73: 1192-200
Smith, III A, Razler T, et al. (2008) Synthesis of (+)-Phorboxazole A Synfacts. 2008: 0671-0671
Smith AB, Razler TM, Meis RM, et al. (2006) Design and synthesis of a potent phorboxazole C(11-15) acetal analogue. Organic Letters. 8: 797-9
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