Michael R. Mish, Ph.D.

Affiliations: 
2001 California Institute of Technology, Pasadena, CA 
Area:
synthesis of natural products
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"Michael Mish"
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Parents

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Erick M. Carreira grad student 2001 Caltech
 (The application of trimethylsilyl diazomethane to the synthesis of optically active pyrazolines and related studies.)
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Publications

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Kirschberg TA, Mish M, Squires NH, et al. (2015) Synthesis of 1'-C-Cyano Pyrimidine Nucleosides and Characterization as HCV Polymerase Inhibitors. Nucleosides, Nucleotides & Nucleic Acids. 1-23
Kirschberg TA, Mish MR, Zhang L, et al. (2015) Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors. Bioorganic & Medicinal Chemistry Letters. 25: 1040-3
Mish MR, Cho A, Kirschberg T, et al. (2014) Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 3092-5
Phillips B, Cai R, Delaney W, et al. (2014) Highly potent HCV NS4B inhibitors with activity against multiple genotypes. Journal of Medicinal Chemistry. 57: 2161-6
Jin H, Metobo S, Jabri S, et al. (2009) Tricyclic HIV integrase inhibitors V. SAR studies on the benzyl moiety. Bioorganic & Medicinal Chemistry Letters. 19: 2263-5
Metobo S, Mish M, Jin H, et al. (2009) Tricyclic HIV integrase inhibitors: VI. SAR studies of 'benzyl flipped' C3-substituted pyrroloquinolines. Bioorganic & Medicinal Chemistry Letters. 19: 1187-90
Jin H, Wright M, Pastor R, et al. (2008) Tricyclic HIV integrase inhibitors: potent and orally bioavailable C5-aza analogs. Bioorganic & Medicinal Chemistry Letters. 18: 1388-91
Fardis M, Jin H, Jabri S, et al. (2006) Effect of substitution on novel tricyclic HIV-1 integrase inhibitors. Bioorganic & Medicinal Chemistry Letters. 16: 4031-5
Guerra FM, Mish MR, Carreira EM. (2000) Versatile, diastereoselective additions of silyl ketene acetals, allyl tributylstannane, and Me(3)SiCN to N-acyl pyrazolines: asymmetric synthesis of densely functionalized pyrazolidines Organic Letters. 2: 4265-7
Guerra FM, Mish MR, Carreira EM. (2000) Versatile, diastereoselective additions of silyl ketene acetals, allyl tributylstannane, and Me3SiCN to N-acyl pyrazolines: Asymmetric synthesis of densely functionalized pyrazolidines Organic Letters. 2: 4265-4267
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