Michael Siu, Ph.D.

Affiliations: 
2002 Harvard University, Cambridge, MA, United States 
Area:
synthesis of natural products
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"Michael Siu"
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SNBCP

Parents

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Andrew G. Myers grad student 2002 Harvard
 (Enantioselective synthesis of (-)-terpestacin.)
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Publications

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Xu J, Carrera DE, Beaudry D, et al. (2020) Fit-for-purpose synthesis of dual leucine zipper kinase (DLK) inhibitor GNE-834 Tetrahedron Letters. 152430
Siu M, Sengupta Ghosh A, Lewcock JW. (2018) Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration. Journal of Medicinal Chemistry
Patel S, Meilandt WJ, Erickson RI, et al. (2017) Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease. Journal of Medicinal Chemistry
Le Pichon CE, Meilandt WJ, Dominguez S, et al. (2017) Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease. Science Translational Medicine. 9
Larhammar M, Huntwork-Rodriguez S, Jiang Z, et al. (2017) Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult. Elife. 6
Takahashi RH, Halladay JS, Siu M, et al. (2017) Novel Mechanism of Decyanation of GDC-0425 by Cytochrome P450. Drug Metabolism and Disposition: the Biological Fate of Chemicals
Patel S, Harris SF, Gibbons P, et al. (2015) Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). Journal of Medicinal Chemistry
Patel S, Cohen F, Dean BJ, et al. (2015) Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. Journal of Medicinal Chemistry. 58: 401-18
Thomas AA, Hunt KW, Newhouse B, et al. (2014) 8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors. Journal of Medicinal Chemistry. 57: 10112-29
Volgraf M, Chan L, Huestis MP, et al. (2014) Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 2477-80
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