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Ming An, Ph.D.

Affiliations:			State University of New York at Binghamton, Vestal, NY, United States
	2003		University of California, Berkeley, Berkeley, CA, United States

Area:

membrane chemical biology, pH-sensitive systems, enzymology

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Mean distance: 7.93

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Parents

Paul Allan Bartlett	grad student	1996-2003	UC Berkeley
(I. 5-enolpyruvylshikimate-3-phosphate synthase: Chemical synthesis of the tetrahedral intermediate and assignment of the stereochemical course of the enzymatic reaction. II. Five-membered ring analogs of shikimate, shikimate-3-phosphate, and 5-enolpyruv)
Donald M. Engelman	post-doc	2007-2011	Yale

Children

Joab O. Onyango	grad student	2011-2014	SUNY Binghamton
Lukas Matthew Klees	grad student	2014-2019	SUNY Binghamton
Anqi Zhang	grad student	2014-2019	SUNY Binghamton

Collaborators

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Publications

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Wachira FW, Githirwa DC, McPartlon T, et al. (2023) D-to-E and T19V Variants of the pH-Low Insertion Peptide and Their Doxorubicin Conjugates Interact with Membrane at Higher pH Ranges Than WT. Biochemistry. 62: 2997-3011
Otieno SA, Klees LM, Zhang A, et al. (2019) The pH-Specific Thermodynamic Intermediates of Phlip Membrane Insertion Biophysical Journal. 116: 513a
Otieno SA, Hanz SZ, Chakravorty B, et al. (2018) pH-dependent thermodynamic intermediates of pHLIP membrane insertion determined by solid-state NMR spectroscopy. Proceedings of the National Academy of Sciences of the United States of America
Zhang A, Yao L, An M. (2017) Reversing the undesirable pH-profile of doxorubicin via activation of a di-substituted maleamic acid prodrug at tumor acidity. Chemical Communications (Cambridge, England)
Osonga FJ, Onyango JO, Mwilu SK, et al. (2017) Synthesis and characterization of novel flavonoid derivatives via sequential phosphorylation of quercetin Tetrahedron Letters. 58: 1474-1479
Hanz SZ, Shu NS, Qian J, et al. (2016) Protonation-Driven Membrane Insertion of a pH-Low Insertion Peptide. Angewandte Chemie (International Ed. in English)
An M, Klees L, Zhang A, et al. (2016) What is the Fate-Determining Step in pHLIP-Mediated Cargo Delivery? Biophysical Journal. 110: 80a
Shu NS, Chung MS, Yao L, et al. (2015) Residue-specific structures and membrane locations of pH-low insertion peptide by solid-state nuclear magnetic resonance. Nature Communications. 6: 7787
Onyango JO, Chung MS, Eng CH, et al. (2015) Noncanonical amino acids to improve the pH response of pHLIP insertion at tumor acidity. Angewandte Chemie (International Ed. in English). 54: 3658-63
Karabadzhak AG, An M, Yao L, et al. (2014) pHLIP-FIRE, a cell insertion-triggered fluorescent probe for imaging tumors demonstrates targeted cargo delivery in vivo. Acs Chemical Biology. 9: 2545-53

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