Joseph M. Simard, Ph.D.

Affiliations: 
2007 Chemistry University of Massachusetts, Amherst, Amherst, MA 
Area:
Supramolecular Chemistry, Nanotechnology
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"Joseph Simard"
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Vincent M. Rotello grad student 2007 U Mass Amherst
 (Synthesis of gold nanoparticles for biomacromolecular recognition.)
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Publications

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Simard JM, Szymanski B, Rotello VM. (2005) Reversible regulation of chymotrypsin activity using negatively charged gold nanoparticles featuring malonic acid termini. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 1: 153-7
Sandanaraj BS, Vutukuri DR, Simard JM, et al. (2005) Noncovalent modification of chymotrypsin surface using an amphiphilic polymer scaffold: implications in modulating protein function. Journal of the American Chemical Society. 127: 10693-8
Verma A, Simard JM, Rotello VM. (2004) Effect of ionic strength on the binding of alpha-chymotrypsin to nanoparticle receptors. Langmuir : the Acs Journal of Surfaces and Colloids. 20: 4178-81
Verma A, Simard JM, Worrall JW, et al. (2004) Tunable reactivation of nanoparticle-inhibited beta-galactosidase by glutathione at intracellular concentrations. Journal of the American Chemical Society. 126: 13987-91
Verma A, Nakade H, Simard JM, et al. (2004) Recognition and stabilization of peptide alpha-helices using templatable nanoparticle receptors. Journal of the American Chemical Society. 126: 10806-7
Verma A, Simard JM, Rotello VM. (2004) Effect of ionic strength on the binding of α-chymotrypsin to nanoparticle receptors Langmuir. 20: 4178-4181
Fischer NO, Verma A, Goodman CM, et al. (2003) Reversible "irreversible" inhibition of chymotrypsin using nanoparticle receptors. Journal of the American Chemical Society. 125: 13387-91
Fischer NO, McIntosh CM, Simard JM, et al. (2002) Inhibition of chymotrypsin through surface binding using nanoparticle-based receptors. Proceedings of the National Academy of Sciences of the United States of America. 99: 5018-23
Sandhu KK, McIntosh CM, Simard JM, et al. (2002) Gold nanoparticle-mediated transfection of mammalian cells. Bioconjugate Chemistry. 13: 3-6
McIntosh CM, Esposito EA, Boal AK, et al. (2001) Inhibition of DNA transcription using cationic mixed monolayer protected gold clusters. Journal of the American Chemical Society. 123: 7626-9
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