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Marcy Hernick, Ph.D.

Affiliations: 
2002 Purdue University, West Lafayette, IN, United States 
Area:
Anticancer Drugs: Design, Synthesis, and Mechanisms of Action
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"Marcy Hernick"
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Richard F. Borch grad student 2002 Purdue
 (The design, synthesis, mechanisms of activation and biological activity of indolequinone phosphoramidate prodrugs.)

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Publications

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Huang X, Hernick M. (2015) Recombinant Expression of a Functional Myo-Inositol-1-Phosphate Synthase (MIPS) in Mycobacterium smegmatis. The Protein Journal
Kocabas E, Liu H, Hernick M. (2015) Identity of cofactor bound to mycothiol conjugate amidase (Mca) influenced by expression and purification conditions. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 28: 755-63
Huang X, Hernick M. (2015) Molecular Determinants of N-Acetylglucosamine Recognition and Turnover by N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-α-D-glucopyranoside Deacetylase (MshB). Biochemistry. 54: 3784-90
Huang X, Hernick M. (2014) Automated docking studies provide insights into molecular determinants of ligand recognition by N-acetyl-1-d-myo-inosityl-2-amino-2-deoxy-α-d-glucopyranoside deacetylase (MshB). Biopolymers. 101: 406-17
Hernick M. (2013) Mycothiol: a target for potentiation of rifampin and other antibiotics against Mycobacterium tuberculosis. Expert Review of Anti-Infective Therapy. 11: 49-67
Huang X, Hernick M. (2012) Examination of mechanism of N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-α-D-glucopyranoside deacetylase (MshB) reveals unexpected role for dynamic tyrosine. The Journal of Biological Chemistry. 287: 10424-34
Huang X, Hernick M. (2011) A limitation of the continuous spectrophotometric assay for the measurement of myo-inositol-1-phosphate synthase activity. Analytical Biochemistry. 417: 228-32
Huang X, Kocabas E, Hernick M. (2011) The activity and cofactor preferences of N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) change depending on environmental conditions. The Journal of Biological Chemistry. 286: 20275-82
Huang X, Hernick M. (2011) A fluorescence-based assay for measuring N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-α-D-glucopyranoside deacetylase activity. Analytical Biochemistry. 414: 278-81
Gattis SG, Hernick M, Fierke CA. (2010) Active site metal ion in UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) switches between Fe(II) and Zn(II) depending on cellular conditions. The Journal of Biological Chemistry. 285: 33788-96
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