Kamil Paruch, Ph.D.

2000 Columbia University, New York, NY 
organic chemistry
"Kamil Paruch"
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Thomas J. Katz grad student 2000 Columbia
 (Efficient synthesis, resolution, and functionalization of helicenes.)
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Němec V, Hylsová M, Maier L, et al. (2018) Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway. Angewandte Chemie (International Ed. in English)
Havel S, Khirsariya P, Akavaram N, et al. (2018) Preparation of 3,4-substituted-5-aminopyrazoles and 4-substituted-2-aminothiazoles. The Journal of Organic Chemistry
Hylse O, Maier L, Kučera R, et al. (2017) A concise synthesis of forskolin. Angewandte Chemie (International Ed. in English)
Samadder P, Suchanková T, Hylse O, et al. (2017) Synthesis and profiling of a novel potent selective inhibitor of CHK1 kinase possessing unusual N-trifluoromethylpyrazole pharmacophore resistant to metabolic N-dealkylation. Molecular Cancer Therapeutics
Maier L, Khirsariya P, Hylse O, et al. (2017) Diastereoselective Flexible Synthesis of Carbocyclic C-nucleosides. The Journal of Organic Chemistry
Hobza P, Nekardová M, Vymětalová L, et al. (2017) Structural basis of interaction of CDK2 with roscovitine and its analogs possessing bioisosteric central heterocycles. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry
Hylsová M, Carbain B, Fanfrlík J, et al. (2016) Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines. European Journal of Medicinal Chemistry. 126: 1118-1128
Kováčová S, Adla SK, Maier L, et al. (2015) Synthesis of carbocyclic analogs of dehydroaltenusin: Identification of a stable inhibitor of calf DNA polymerase α Tetrahedron. 71: 7575-7582
Maier L, Hylse O, Nečas M, et al. (2014) New carbocyclic nucleosides: Synthesis of carbocyclic pseudoisocytidine and its analogs Tetrahedron Letters. 55: 3713-3716
Labroli MA, Dwyer MP, Shen R, et al. (2014) Syntheses of 5′-amino-2′,5′-dideoxy-2′,2′- difluorocytidine derivatives as novel anticancer nucleoside analogs Tetrahedron Letters. 55: 598-602
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