Thomas M. Makris, Ph.D.

Affiliations: 
2004 University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
Area:
metalloenzymes
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Stephen G. Sligar grad student 2004 UIUC
 (Isolation and characterization of reactive heme -oxygen intermediates in cytochrome P450 catalysis.)
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Publications

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Amaya JA, Manley OM, Bian JC, et al. (2023) Enhancing ferryl accumulation in HO-dependent cytochrome P450s. Journal of Inorganic Biochemistry. 252: 112458
Gering HE, Li X, Tang H, et al. (2023) A Ferric-Superoxide Intermediate Initiates P450-Catalyzed Cyclic Dipeptide Dimerization. Journal of the American Chemical Society
Rade LL, Generoso WC, Das S, et al. (2023) Dimer-assisted mechanism of (un)saturated fatty acid decarboxylation for alkene production. Proceedings of the National Academy of Sciences of the United States of America. 120: e2221483120
Manley OM, Phan HN, Stewart AK, et al. (2022) Self-sacrificial tyrosine cleavage by an Fe:Mn oxygenase for the biosynthesis of -aminobenzoate in . Proceedings of the National Academy of Sciences of the United States of America. 119: e2210908119
Dutra M, Amaya JA, McElhenney S, et al. (2022) Experimental and Theoretical Examination of the Kinetic Isotope Effect in Cytochrome P450 Decarboxylase OleT. The Journal of Physical Chemistry. B. 126: 3493-3504
Manley OM, Tang H, Xue S, et al. (2021) BesC Initiates C-C Cleavage through a Substrate-Triggered and Reactive Diferric-Peroxo Intermediate. Journal of the American Chemical Society. 143: 21416-21424
Zhang L, Manley OM, Ma D, et al. (2020) Enhanced P450 fatty acid decarboxylase catalysis by glucose oxidase coupling and co-assembly for biofuel generation. Bioresource Technology. 311: 123538
Kaniusaite M, Goode RJA, Schittenhelm RB, et al. (2019) The Diiron Monooxygenase CmlA from Chloramphenicol Biosynthesis Allows Reconstitution of β-Hydroxylation during Glycopeptide Antibiotic Biosynthesis. Acs Chemical Biology
Blahut M, Wise CE, Bruno MR, et al. (2019) Direct observation of intermediates in the SufS cysteine desulfurase reaction reveals functional roles of conserved active-site residues. The Journal of Biological Chemistry
Manley OM, Fan R, Guo Y, et al. (2019) The oxidative decarboxylase UndA utilizes a dinuclear iron cofactor. Journal of the American Chemical Society
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