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Amy L. Eastwood, Ph.D.

Affiliations: 
2009 Chemistry California Institute of Technology, Pasadena, CA 
Area:
physical organic chemistry to systems of biological importance
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"Amy Eastwood"
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Dennis A. Dougherty grad student 2009 Caltech
 (Investigating Structure-Function Relationships in Ion Channels Using Unnatural Amino Acids.)

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Publications

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Eastwood AL, Goodman MB. (2012) Insight into DEG/ENaC channel gating from genetics and structure. Physiology (Bethesda, Md.). 27: 282-90
Ahern CA, Eastwood AL, Dougherty DA, et al. (2009) An electrostatic interaction between TEA and an introduced pore aromatic drives spring-in-the-door inactivation in Shaker potassium channels. The Journal of General Physiology. 134: 461-9
Eastwood AL, Blum AP, Zacharias NM, et al. (2009) A selenide-based approach to photochemical cleavage of peptide and protein backbones at engineered backbone esters. The Journal of Organic Chemistry. 74: 9241-4
Ahern CA, Eastwood AL, Dougherty DA, et al. (2008) New insights into the therapeutic inhibition of voltage-gated sodium channels. Channels (Austin, Tex.). 2: 1-3
Ahern CA, Eastwood AL, Dougherty DA, et al. (2008) Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels. Circulation Research. 102: 86-94
Santarelli VP, Eastwood AL, Dougherty DA, et al. (2007) Calcium block of single sodium channels: role of a pore-lining aromatic residue. Biophysical Journal. 93: 2341-9
Santarelli VP, Eastwood AL, Dougherty DA, et al. (2007) A cation-pi interaction discriminates among sodium channels that are either sensitive or resistant to tetrodotoxin block. The Journal of Biological Chemistry. 282: 8044-51
Ahern CA, Eastwood AL, Lester HA, et al. (2006) A cation-pi interaction between extracellular TEA and an aromatic residue in potassium channels. The Journal of General Physiology. 128: 649-57
Kumar R, Eastwood AL, Brown ML, et al. (2002) Human genome search in celiac disease: mutated gliadin T-cell-like epitope in two human proteins promotes T-cell activation. Journal of Molecular Biology. 319: 593-602
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