Rebecca T. Ruck, Ph.D.

Affiliations: 
2003 Harvard University, Cambridge, MA, United States 
Area:
Mechanistic and synthetic chemistry
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"Rebecca Ruck"
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Eric N. Jacobsen grad student 2003 Harvard
 (Chromium(III)-catalyzed asymmetric pericyclic reactions: Discovery and mechanism.)
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Publications

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Metsänen TT, Lexa KW, Santiago CB, et al. (2018) Combining traditional 2D and modern physical organic-derived descriptors to predict enhanced enantioselectivity for the key aza-Michael conjugate addition in the synthesis of Prevymis™ (letermovir). Chemical Science. 9: 6922-6927
Xu F, Zhong YL, Li H, et al. (2017) Asymmetric Synthesis of Functionalized trans-Cyclopropoxy Building Block for Grazoprevir. Organic Letters
Chung CK, Liu Z, Lexa K, et al. (2017) Asymmetric Hydrogen Bonding Catalysis for the Synthesis of Dihydroquinazoline-containing Antiviral, Letermovir. Journal of the American Chemical Society
Ji Y, Li H, Hyde AM, et al. (2017) A rational pre-catalyst design for bis-phosphine mono-oxide palladium catalyzed reactions. Chemical Science. 8: 2841-2851
McCabe Dunn JM, Reibarkh M, Sherer EC, et al. (2017) The protecting-group free selective 3'-functionalization of nucleosides. Chemical Science. 8: 2804-2810
DiRocco DA, Ji Y, Sherer EC, et al. (2017) A multifunctional catalyst that stereoselectively assembles prodrugs. Science (New York, N.Y.). 356: 426-430
Chung CK, Cleator E, Dumas AM, et al. (2016) A Synthesis of a Spirocyclic Macrocyclic Protease Inhibitor for the Treatment of Hepatitis C. Organic Letters
Neelamkavil SF, Agrawal S, Bara T, et al. (2016) Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor. Acs Medicinal Chemistry Letters. 7: 111-6
Christensen M, Nolting A, Shevlin M, et al. (2016) Enantioselective Synthesis of α-Methyl-β-Cyclopropyldihydrocinnamates. The Journal of Organic Chemistry
Bassan E, Ruck RT, Dienemann E, et al. (2013) Merck's Reaction Review Policy: An Exercise in Process Safety Organic Process Research and Development. 17: 1611-1616
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