Ranepuradewage E. Chandrasena, Ph.D.

Affiliations: 
2006 University of Illinois at Chicago, Chicago, IL, United States 
Area:
radical chemistry
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"Ranepuradewage Chandrasena"
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Martin E. Newcomb grad student 2006 University of Illinois, Chicago
 (Multiple electrophilic oxidants in cytochrome P450 and photochemical generation of compound I.)
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Publications

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Hemachandra LP, Patel H, Chandrasena RE, et al. (2014) SERMs attenuate estrogen-induced malignant transformation of human mammary epithelial cells by upregulating detoxification of oxidative metabolites. Cancer Prevention Research (Philadelphia, Pa.). 7: 505-15
Michalsen BT, Gherezghiher TB, Choi J, et al. (2012) Selective estrogen receptor modulator (SERM) lasofoxifene forms reactive quinones similar to estradiol. Chemical Research in Toxicology. 25: 1472-83
Gherezghiher TB, Michalsen B, Chandrasena RE, et al. (2012) The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin. Chemico-Biological Interactions. 196: 1-10
Abdul-Hay S, Schiefer IT, Chandrasena RE, et al. (2011) NO-SSRIs: Nitric Oxide Chimera Drugs Incorporating a Selective Serotonin Reuptake Inhibitor. Acs Medicinal Chemistry Letters. 2: 656-661
Sinha V, Wijewickrama GT, Chandrasena RE, et al. (2010) Proteomic and mass spectroscopic quantitation of protein S-nitrosation differentiates NO-donors. Acs Chemical Biology. 5: 667-80
Kim HY, Sohn J, Wijewickrama GT, et al. (2010) Click synthesis of estradiol-cyclodextrin conjugates as cell compartment selective estrogens. Bioorganic & Medicinal Chemistry. 18: 809-21
Hagos GK, Abdul-Hay SO, Sohn J, et al. (2008) Anti-inflammatory, antiproliferative, and cytoprotective activity of NO chimera nitrates of use in cancer chemoprevention. Molecular Pharmacology. 74: 1381-91
Chandrasena RE, Edirisinghe PD, Bolton JL, et al. (2008) Problematic detoxification of estrogen quinones by NAD(P)H-dependent quinone oxidoreductase and glutathione-S-transferase. Chemical Research in Toxicology. 21: 1324-9
Dunlap T, Abdul-Hay SO, Chandrasena RE, et al. (2008) Nitrates and NO-NSAIDs in cancer chemoprevention and therapy: in vitro evidence querying the NO donor functionality. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 19: 115-24
Dunlap T, Chandrasena RE, Wang Z, et al. (2007) Quinone formation as a chemoprevention strategy for hybrid drugs: balancing cytotoxicity and cytoprotection. Chemical Research in Toxicology. 20: 1903-12
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