Jonathan R. LaRochelle, Ph.D.
Affiliations: | 2014 | Molecular, Cellular & Developmental Biology | Yale University, New Haven, CT |
| 2014- | Biological Chemistry & Molecular Pharmacology | Harvard University, Cambridge, MA, United States |
Area:
protein–protein and protein-small molecule interactionsGoogle:
"Jonathan LaRochelle"Mean distance: 7.72
Parents
Sign in to add mentor| Alanna Schepartz | grad student | 2014 | Yale | |
| (Enhancing the Cytosolic Delivery of Therapeutic Peptides.) | ||||
| Stephen C. Blacklow | post-doc | |||
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Publications
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| Vemulapalli V, Chylek LA, Erickson A, et al. (2021) Time resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling. Elife. 10 |
| Steinauer A, LaRochelle JR, Knox SL, et al. (2019) HOPS-dependent endosomal fusion required for efficient cytosolic delivery of therapeutic peptides and small proteins. Proceedings of the National Academy of Sciences of the United States of America. 116: 512-521 |
| LaRochelle JR, Fodor M, Vemulapalli V, et al. (2018) Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. Nature Communications. 9: 4508 |
| Fodor M, Price E, Wang P, et al. (2018) Dual Allosteric Inhibition of SHP2 Phosphatase. Acs Chemical Biology |
| Quach K, LaRochelle J, Li XH, et al. (2017) Unique arginine array improves cytosolic localization of hydrocarbon-stapled peptides. Bioorganic & Medicinal Chemistry |
| LaRochelle JR, Fodor M, Ellegast JM, et al. (2017) Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2. Bioorganic & Medicinal Chemistry |
| Acker MG, Chen YP, LaMarche MJ, et al. (2017) Abstract 2084: Conformational activation and allosteric inhibition of SHP2 in RTK-driven cancers Cancer Research. 77: 2084-2084 |
| LaRochelle JR, Fodor M, Xu X, et al. (2016) Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2. Biochemistry |
| Li M, Tao Y, Shu Y, et al. (2015) Discovery and characterization of a peptide that enhances endosomal escape of delivered proteins in vitro and in vivo. Journal of the American Chemical Society |
| LaRochelle JR, Cobb GB, Steinauer A, et al. (2015) Fluorescence correlation spectroscopy reveals highly efficient cytosolic delivery of certain penta-arg proteins and stapled peptides. Journal of the American Chemical Society. 137: 2536-41 |