Ryan M. Phelan, Ph.D.
Affiliations: | 2011 | Johns Hopkins University, Baltimore, MD |
Area:
Organic and Bioorganic ChemistryGoogle:
"Ryan Phelan"Mean distance: 8.94 | S | N | B | C | P |
Parents
Sign in to add mentor| Craig A. Townsend | grad student | 2011 | Johns Hopkins | |
| (Mechanistic investigations into formation of the (5R)-carbapenem by carbapenem synthase (CarC) and efforts toward expansion of CarC substrate tolerance.) | ||||
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Publications
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| Phelan RM, Townsend CA. (2013) Mechanistic insights into the bifunctional non-heme iron oxygenase carbapenem synthase by active site saturation mutagenesis. Journal of the American Chemical Society. 135: 7496-502 |
| Phelan RM, DiPardo BJ, Townsend CA. (2012) A high-throughput screen for the engineered production of β-lactam antibiotics. Acs Chemical Biology. 7: 835-40 |
| Bodner MJ, Li R, Phelan RM, et al. (2011) Definition of the common and divergent steps in carbapenem β-lactam antibiotic biosynthesis. Chembiochem : a European Journal of Chemical Biology. 12: 2159-65 |
| Bodner MJ, Phelan RM, Freeman MF, et al. (2010) Non-heme iron oxygenases generate natural structural diversity in carbapenem antibiotics. Journal of the American Chemical Society. 132: 12-3 |
| Bodner MJ, Phelan RM, Townsend CA. (2009) A catalytic asymmetric route to carbapenems. Organic Letters. 11: 3606-9 |
| Sohka T, Heins RA, Phelan RM, et al. (2009) An externally tunable bacterial band-pass filter. Proceedings of the National Academy of Sciences of the United States of America. 106: 10135-40 |
| Phelan RM, Ostermeier M, Townsend CA. (2009) Design and synthesis of a beta-lactamase activated 5-fluorouracil prodrug. Bioorganic & Medicinal Chemistry Letters. 19: 1261-3 |