Malken Bayrakdarian, Ph.D.

2002 Université de Montréal, Montréal, Canada 
chemistry of natural products
"Malken Bayrakdarian"
Mean distance: 10.31


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Stephen Hanessian grad student 2002 Université de Montréal
 (Synthese asymetrique d'heterocycles substitues d'interets biologiques.)
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Cantin LD, Bayrakdarian M, Buon C, et al. (2012) Discovery of P2X3 selective antagonists for the treatment of chronic pain. Bioorganic & Medicinal Chemistry Letters. 22: 2565-71
Hanessian S, Simard D, Bayrakdarian M, et al. (2008) Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs. Bioorganic & Medicinal Chemistry Letters. 18: 1972-6
Hanessian S, Therrien E, van Otterlo WA, et al. (2006) Phenolic P2/P3 core motif as thrombin inhibitors--design, synthesis, and X-ray co-crystal structure. Bioorganic & Medicinal Chemistry Letters. 16: 1032-6
Hanessian S, Hou Y, Bayrakdarian M, et al. (2005) Stereoselective synthesis of constrained oxacyclic hydroxyethylene isosteres of aspartic protease inhibitors: aldol and Mukaiyama aldol methodologies for branched tetrahydrofuran 2-carboxylic acids. The Journal of Organic Chemistry. 70: 6735-45
Hanessian S, Yun H, Hou Y, et al. (2005) Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics. Journal of Medicinal Chemistry. 48: 5175-90
Hanessian S, Buckle R, Bayrakdarian M. (2002) Design and synthesis of a novel class of constrained tricyclic pyrrolizidinone carboxylic acids as carbapenem mimics. The Journal of Organic Chemistry. 67: 3387-97
Hanessian S, Bayrakdarian M, Luo X. (2002) Total synthesis of A-315675: a potent inhibitor of influenza neuraminidase. Journal of the American Chemical Society. 124: 4716-21
Hanessian S, Bayrakdarian M. (2002) Solution- and solid-phase asymmetric synthesis of substituted N-hydroxypyrrolidine dicarboxylic acids Tetrahedron Letters. 43: 9441-9444
Hanessian S, Bayrakdarian M. (2002) Asymmetric synthesis of diversely substituted N-hydroxypyrrolidines using cycloadditions with chiral nitrone enolate/ylids Tetrahedron Letters. 43: 967-971
Hanessian S, Bayrakdarian M. (2000) Pyrrolidine as a cogwheel-like scaffold for the deployment of diverse functionality through cycloaddition reactions of metallo-1,3-dipoles in aqueous media. Bioorganic & Medicinal Chemistry Letters. 10: 427-31
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