Elizaveta Freinkman, Ph.D.

Affiliations: 
2012 Chemical Biology Harvard University, Cambridge, MA, United States 
Area:
molecular mechanisms of various antibiotics
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"Elizaveta Freinkman"
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Daniel E. Kahne grad student 2012 Harvard
 (Assembly and Regulation of the Lipopolysaccharide Transporter.)
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Publications

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Garcia-Bermudez J, Baudrier L, Bayraktar EC, et al. (2019) Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. Nature
Kanarek N, Keys HR, Cantor JR, et al. (2018) Histidine catabolism is a major determinant of methotrexate sensitivity. Nature
Mihaylova MM, Cheng CW, Cao AQ, et al. (2018) Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging. Cell Stem Cell. 22: 769-778.e4
Chen WW, Freinkman E, Sabatini DM. (2017) Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites. Nature Protocols. 12: 2215-2231
Abu-Remaileh M, Wyant GA, Kim C, et al. (2017) Lysosomal metabolomics reveals V-ATPase and mTOR-dependent regulation of amino acid efflux from lysosomes. Science (New York, N.Y.)
Wyant GA, Abu-Remaileh M, Wolfson RL, et al. (2017) mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient. Cell. 171: 642-654.e12
Ilic N, Birsoy K, Aguirre AJ, et al. (2017) PIK3CA mutant tumors depend on oxoglutarate dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America
Cantor JR, Abu-Remaileh M, Kanarek N, et al. (2017) Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase. Cell. 169: 258-272.e17
Kanarek N, Freinkman E, Cantor J, et al. (2017) Abstract 4988: Genome-wide CRISPR screen and metabolite profiling reveal a new mechanism of methotrexate sensitivity Cancer Research. 77: 4988-4988
Mayers JR, Torrence ME, Danai LV, et al. (2016) Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers. Science (New York, N.Y.). 353: 1161-5
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