Sean F. Brady, Ph.D.

Affiliations: 
2007- Rockefeller University, New York, NY, United States 
Area:
natural products
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SNBCP

Parents

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Jon C. Clardy grad student 2002 Cornell
 (Chemical diversity from biodiversity: Natural products from endophytic fungi and uncultured bacteria.)

Children

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John Chu post-doc Rockefeller
John Biggins post-doc 2010-2016 Rockefeller
ZHUO SHANG post-doc 2018-2019 Rockefeller
Nicholas A. Forelli research scientist 2018-2021 Rockefeller
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Publications

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Wang Z, Koirala B, Hernandez Y, et al. (2022) Discovery of Paenibacillaceae Family Gram-Negative-Active Cationic Lipopeptide Antibiotics Using Evolution-Guided Chemical Synthesis. Organic Letters
Wang Z, Koirala B, Hernandez Y, et al. (2022) Bioinformatic prospecting and synthesis of a bifunctional lipopeptide antibiotic that evades resistance. Science (New York, N.Y.). 376: 991-996
Wang Z, Forelli N, Hernandez Y, et al. (2022) Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis. Nature Communications. 13: 842
Wang Z, Koirala B, Hernandez Y, et al. (2022) A naturally inspired antibiotic to target multidrug-resistant pathogens. Nature
Peek J, Koirala B, Brady SF. (2022) Synthesis and evaluation of dual-action kanglemycin-fluoroquinolone hybrid antibiotics. Bioorganic & Medicinal Chemistry Letters. 57: 128484
Li L, Koirala B, Hernandez Y, et al. (2021) Identification of structurally diverse menaquinone-binding antibiotics with in vivo activity against multidrug-resistant pathogens. Nature Microbiology
Piscotta FJ, Hoffmann HH, Choi YJ, et al. (2021) Metabolites with SARS-CoV-2 Inhibitory Activity Identified from Human Microbiome Commensals. Msphere. e0071121
Wang Z, Kasper A, Mehmood R, et al. (2021) Metagenome guided analog synthesis yields improved Gram-negative active albicidin and cystobactamid type antibiotics. Angewandte Chemie (International Ed. in English)
Li L, MacIntyre LW, Ali T, et al. (2021) Biosynthetic Interrogation of Soil Metagenomes Reveals Metamarin, an Uncommon Cyclomarin Congener with Activity against . Journal of Natural Products
Dror B, Wang Z, Brady SF, et al. (2020) Elucidating the Diversity and Potential Function of Nonribosomal Peptide and Polyketide Biosynthetic Gene Clusters in the Root Microbiome. Msystems. 5
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