Brian P. Smart, Ph.D.
Affiliations: | 2006 | University of Washington, Seattle, Seattle, WA |
Area:
medicinal enzymologyGoogle:
"Brian Smart"Mean distance: 9.11 | S | N | B | C | P |
Parents
Sign in to add mentor| Michael H. Gelb | grad student | 2006 | University of Washington | |
| (Structure-based design of secreted and cytosolic phospholipase A2 inhibitors.) | ||||
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Publications
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| Bryant KJ, Bidgood MJ, Lei PW, et al. (2011) A bifunctional role for group IIA secreted phospholipase A2 in human rheumatoid fibroblast-like synoviocyte arachidonic acid metabolism. The Journal of Biological Chemistry. 286: 2492-503 |
| Bendale P, Olepu S, Suryadevara PK, et al. (2007) Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials. Journal of Medicinal Chemistry. 50: 4585-605 |
| Van Voorhis WC, Rivas KL, Bendale P, et al. (2007) Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase. Antimicrobial Agents and Chemotherapy. 51: 3659-71 |
| Smart BP, Oslund RC, Walsh LA, et al. (2006) The first potent inhibitor of mammalian group X secreted phospholipase A2: elucidation of sites for enhanced binding. Journal of Medicinal Chemistry. 49: 2858-60 |
| Ni Z, Okeley NM, Smart BP, et al. (2006) Intracellular actions of group IIA secreted phospholipase A2 and group IVA cytosolic phospholipase A2 contribute to arachidonic acid release and prostaglandin production in rat gastric mucosal cells and transfected human embryonic kidney cells. The Journal of Biological Chemistry. 281: 16245-55 |
| Rubin BB, Downey GP, Koh A, et al. (2005) Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity. The Journal of Biological Chemistry. 280: 7519-29 |
| Smart BP, Pan YH, Weeks AK, et al. (2004) Inhibition of the complete set of mammalian secreted phospholipases A(2) by indole analogues: a structure-guided study. Bioorganic & Medicinal Chemistry. 12: 1737-49 |
| Degousee N, Ghomashchi F, Stefanski E, et al. (2002) Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis. The Journal of Biological Chemistry. 277: 5061-73 |