Brian N. Cook, Ph.D.

Affiliations: 
2002 University of California, Berkeley, Berkeley, CA 
Area:
Bioorthogonal chemistry
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"Brian Cook"
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Carolyn R. Bertozzi grad student 2002 UC Berkeley
 (Substrates and inhibitors of carbohydrate sulfotransferases.)
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Publications

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Cook BN, Bentzien J, White A, et al. (2009) Discovery of potent inhibitors of interleukin-2 inducible T-cell kinase (ITK) through structure-based drug design. Bioorganic & Medicinal Chemistry Letters. 19: 773-7
Moriarty KJ, Takahashi H, Pullen SS, et al. (2009) Corrigendum to "Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)" [Bioorg. Med. Chem. Lett. 18 (2008) 5545-5549] (DOI:10.1016/j.bmcl.2008.09.015) Bioorganic and Medicinal Chemistry Letters. 19: 1835
Moriarty KJ, Takahashi H, Pullen SS, et al. (2008) Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk). Bioorganic & Medicinal Chemistry Letters. 18: 5545-9
Moriarty KJ, Winters M, Qiao L, et al. (2008) Itk kinase inhibitors: initial efforts to improve the metabolical stability and the cell activity of the benzimidazole lead. Bioorganic & Medicinal Chemistry Letters. 18: 5537-40
Cook BN, Bertozzi CR. (2002) Chemical approaches to the investigation of cellular systems. Bioorganic & Medicinal Chemistry. 10: 829-40
Kehoe JW, Maly DJ, Verdugo DE, et al. (2002) Tyrosylprotein sulfotransferase inhibitors generated by combinatorial target-guided ligand assembly. Bioorganic & Medicinal Chemistry Letters. 12: 329-32
Bowman KG, Cook BN, de Graffenried CL, et al. (2001) Biosynthesis of L-selectin ligands: sulfation of sialyl Lewis x-related oligosaccharides by a family of GlcNAc-6-sulfotransferases. Biochemistry. 40: 5382-91
Bhakta S, Bartes A, Bowman KG, et al. (2000) Sulfation of N-acetylglucosamine by chondroitin 6-sulfotransferase 2 (GST-5). The Journal of Biological Chemistry. 275: 40226-34
Armstrong JI, Portley AR, Chang YT, et al. (2000) Discovery of Carbohydrate Sulfotransferase Inhibitors from a Kinase-Directed Library We thank Sharon Long and Dave Keating for providing both the NodH sulfotransferase and APS Kinase during our preliminary experiments and Jack Kirsch for numerous helpful conversations. J.I.A. and K.G.B were supported by NIH Molecular Biophysics Training Grant (No. T32GM0895). This research was funded by grants to C.R.B. from the Pew Scholars Program, the W. M. Keck Foundation and the American Cancer Society (Grant No. RPG9700501BE). Angewandte Chemie (International Ed. in English). 39: 1303-1306
Cook BN, Bhakta S, Biegel T, et al. (2000) Differential carbohydrate recognition of two GlcNAc-6-sulfotransferases with possible roles in L-selectin ligand biosynthesis Journal of the American Chemical Society. 122: 8612-8622
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