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Changshou Gao, Ph.D.

Affiliations: 
2002 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Medicinal chemistry
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"Changshou Gao"
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Kim David Janda grad student 2002 Scripps Institute
 (Development of protein VII and protein IX as the new platforms for phage display.)

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Zou J, Li L, Zheng P, et al. (2022) Ultrapotent neutralizing antibodies against SARS-CoV-2 with a high degree of mutation resistance. The Journal of Clinical Investigation. 132
Dimasi N, Kumar A, Gao C. (2021) Generation of bispecific antibodies using chemical conjugation methods. Drug Discovery Today. Technologies. 40: 13-24
Kumar A, Mao S, Dimasi N, et al. (2020) Design and Validation of Linkers for Site-Specific Preparation of Antibody-Drug Conjugates Carrying Multiple Drug Copies Per Cysteine Conjugation Site. International Journal of Molecular Sciences. 21
Steinhardt J, Wu Y, Fleming R, et al. (2019) Fab-Arm Exchange Combined with Selective Protein A Purification Results in a Platform for Rapid Preparation of Monovalent Bispecific Antibodies Directly from Culture Media. Pharmaceutics. 12
St Amant AH, Huang F, Lin J, et al. (2019) A Reactive Antibody Platform for One-Step Production of Antibody-Drug Conjugates Through a Diels-Alder Reaction with Maleimide. Bioconjugate Chemistry
Li JY, Perry SR, Muniz-Medina V, et al. (2019) A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy. Cancer Cell. 35: 948-949
St Amant AH, Huang F, Lin J, et al. (2019) A Diene-Containing Noncanonical Amino Acid Enables Dual Functionality in Proteins: Rapid Diels-Alder Reaction with Maleimide or Proximity-Based Dimerization. Angewandte Chemie (International Ed. in English)
Ruddle BT, Fleming R, Wu H, et al. (2019) Characterization of disulfide bond rebridged Fab-drug conjugates prepared using a dual maleimide pyrrolobenzodiazepine cytotoxic payload. Chemmedchem
Li Q, Barrett A, Vijayakrishnan B, et al. (2019) Improved Inhibition of Tumor Growth by Diabody-Drug Conjugates via Half-Life Extension. Bioconjugate Chemistry
White JB, Fleming R, Masterson L, et al. (2019) Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer. Mabs. 1-16
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