Alice L. Rodriguez, Ph.D.
Affiliations: | 2003 | University of Illinois, Urbana-Champaign, Urbana-Champaign, IL |
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"Alice Rodriguez"Mean distance: 8.52 | S | N | B | C | P |
Parents
Sign in to add mentor| John A. Katzenellenbogen | grad student | 2003 | UIUC | |
| (I. The development of estrogen receptor coactivator binding inhibitors. II. Investigations into the binding modes of ligands selective for estrogen receptor alpha.) | ||||
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Publications
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| Qi A, Kling HE, Billard N, et al. (2023) . Molecular Pharmacology |
| Lei X, Hofmann C, Rodriguez AL, et al. (2023) Differential Activity of Orthosteric Agonists and Allosteric Modulators at Metabotropic Glutamate Receptor 7. Molecular Pharmacology |
| Kalbfleisch JJ, Rodriguez AL, Lei X, et al. (2022) Persistent challenges in the development of an mGlu PAM in vivo tool compound: The discovery of VU6046980. Bioorganic & Medicinal Chemistry Letters. 80: 129106 |
| Orsi DL, Felts AS, Rodriguez AL, et al. (2022) Discovery of a potent M antagonist with improved clearance profile. Part 2: pyrrolidine amide-based antagonists. Bioorganic & Medicinal Chemistry Letters. 129021 |
| Capstick RA, Whomble D, Orsi DL, et al. (2022) Discovery of a potent M antagonist with improved clearance profile. Part 1: Piperidine amide-based antagonists. Bioorganic & Medicinal Chemistry Letters. 76: 128988 |
| Reed CW, Rodriguez AL, Kalbfleisch JJ, et al. (2022) Development and profiling of mGlu NAMs with a range of saturable inhibition of agonist responses in vitro. Bioorganic & Medicinal Chemistry Letters. 74: 128923 |
| Barbaro L, Rodriguez AL, Blevins AN, et al. (2021) Discovery of "Molecular Switches" within a Series of mGlu Allosteric Ligands Driven by a "Magic Methyl" Effect Affording Both PAMs and NAMs with Activity, Derived from an M PAM Chemotype. Acs Bio & Med Chem Au. 1: 21-30 |
| Bender AM, Carter TR, Spock M, et al. (2021) Synthesis and Characterization of Chiral 6-Azaspiro[2.5]Octanes as Potent and Selective Antagonists of the M Muscarinic Acetylcholine Receptor. Bioorganic & Medicinal Chemistry Letters. 128479 |
| Yamada Y, Gilliland K, Xiang Z, et al. (2021) Positive allosteric modulators (PAMs) of the group II metabotropic glutamate receptors: Design, synthesis, and evaluation as ex-vivo tool compounds. Bioorganic & Medicinal Chemistry Letters. 128342 |
| Moehle MS, Bender AM, Dickerson JW, et al. (2021) Discovery of the First Selective M Muscarinic Acetylcholine Receptor Antagonists with Antiparkinsonian and Antidystonic Efficacy. Acs Pharmacology & Translational Science. 4: 1306-1321 |