Richard S. Agnes, Ph.D.

Affiliations: 
2003 University of Arizona, Tucson, AZ 
Area:
Organic Chemistry, Biochemistry, Chemical Biology and Medicinal Chemistry
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Victor J. Hruby grad student 2003 University of Arizona
 (New paradigm for drug design: Design and synthesis of novel biologically active peptides that are agonists at opioid receptors and antagonists at cholecystokinin receptors.)
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Publications

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Hanlon KE, Herman DS, Agnes RS, et al. (2011) Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain. Brain Research. 1395: 1-11
Zhang W, Gardell S, Zhang D, et al. (2009) Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors. Brain : a Journal of Neurology. 132: 778-87
Agnes RS, Ying J, Kövér KE, et al. (2008) Structure-activity relationships of bifunctional cyclic disulfide peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. Peptides. 29: 1413-23
Lee YS, Agnes RS, Cain JP, et al. (2008) Opioid and melanocortin receptors: do they have overlapping pharmacophores? Biopolymers. 90: 433-8
Lee YS, Nyberg J, Moye S, et al. (2007) Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors. Bioorganic & Medicinal Chemistry Letters. 17: 2161-5
Lee YS, Agnes RS, Davis P, et al. (2007) Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. Journal of Medicinal Chemistry. 50: 165-8
Hruby VJ, Porreca F, Yamamura HI, et al. (2006) New paradigms and tools in drug design for pain and addiction. The Aaps Journal. 8: E450-60
Agnes RS, Lee YS, Davis P, et al. (2006) Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. Journal of Medicinal Chemistry. 49: 2868-75
Lee YS, Agnes RS, Badghisi H, et al. (2006) Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. Journal of Medicinal Chemistry. 49: 1773-80
Gu X, Ying J, Agnes RS, et al. (2004) Novel design of bicyclic beta-turn dipeptides on solid-phase supports and synthesis of [3.3.0]-Bicyclo([2,3])-leu-enkephalin analogues. Organic Letters. 6: 3285-8
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