Hongchang Qu, Ph.D.

Affiliations: 
2007 Chemistry University of Arizona, Tucson, AZ 
Area:
Organic Chemistry, Biochemistry, Chemical Biology and Medicinal Chemistry
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"Hongchang Qu"
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Victor J. Hruby grad student 2007 University of Arizona
 (Synthesis of novel amino acids and use of peptides & peptidomimetics containing unnatural amino acids for the development of selective melanocortin peptide antagonists and for the study of melanocortin receptor signaling.)
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Publications

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Hu H, Ransdell AS, Qu H, et al. (2023) Probing the Binding Mechanism of Acylated Peptides to Human Serum Albumin. Acs Chemical Biology. 18: 1158-1167
Adare A, Afanasiev S, Aidala C, et al. (2015) Measurements of Elliptic and Triangular Flow in High-Multiplicity 3He+Au Collisions at √(s(NN))=200 GeV. Physical Review Letters. 115: 142301
Adare A, Aidala C, Ajitanand NN, et al. (2015) Measurement of Long-Range Angular Correlation and Quadrupole Anisotropy of Pions and (Anti)Protons in Central d+Au Collisions at sqrt[s_{NN}]=200 GeV. Physical Review Letters. 114: 192301
Lee YS, Qu HC, Davis P, et al. (2013) Chiral Effect of a Phe Residue in Position 3 of the Dmt(1)-L(or D)-Tic(2) Analogues on Opioid Functional Activities. Acs Medicinal Chemistry Letters. 4: 656-659
Liu Z, Mehta SJ, Lee KS, et al. (2012) Thio-Claisen rearrangement used in preparing anti-β-functionalized γ,δ-unsaturated amino acids: scope and limitations. The Journal of Organic Chemistry. 77: 1289-300
Cai M, Liu Z, Qu H, et al. (2011) Utilize conjugated melanotropins for the earlier diagnosis and treatment of melanoma. European Journal of Pharmacology. 660: 188-93
Liu Z, Qu H, Gu X, et al. (2010) Novel anti-β-functionalized γ,δ-unsaturated amino acids via a thio-Claisen rearrangement Tetrahedron Letters. 51: 3518-3520
Qu H, Cai M, Mayorov AV, et al. (2009) Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor. Journal of Medicinal Chemistry. 52: 3627-35
Hruby VJ, Cai M, Dedek M, et al. (2009) Peptide and non-peptide mimetics utilize different pathways for signal transduction. Advances in Experimental Medicine and Biology. 611: 305-7
Yang Y, Cai M, Chen M, et al. (2009) Key amino acid residues in the melanocortin-4 receptor for nonpeptide THIQ specific binding and signaling. Regulatory Peptides. 155: 46-54
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