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Isuru R. Kumarasinghe, Ph.D.

Affiliations: 
2010 Chemistry University of Arizona, Tucson, AZ 
Area:
Organic Chemistry, Biochemistry, Chemical Biology and Medicinal Chemistry
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"Isuru Kumarasinghe"
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Victor J. Hruby grad student 2010 University of Arizona
 (Design, synthesis, NMR conformational analysis and docking analysis of novel multifuntional molecules for pain.)

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Publications

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Kumarasinghe IR, Woster PM. (2018) Cyclic by peptide inhibitors of lysine-specific demethylase 1 with improved potency identified by alanine scanning mutagenesis. European Journal of Medicinal Chemistry. 148: 210-220
Kumarasinghe IR, Woster PM. (2014) Synthesis and evaluation of novel cyclic Peptide inhibitors of lysine-specific demethylase 1. Acs Medicinal Chemistry Letters. 5: 29-33
Hanlon KE, Herman DS, Agnes RS, et al. (2011) Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain. Brain Research. 1395: 1-11
Kumarasinghe IR, Hruby VJ, Nichol GS. (2009) 1-(4-Methoxy-phen-yl)-3-phenyl-1H-pyrazol-5-amine. Acta Crystallographica. Section E, Structure Reports Online. 65: o1170
Vardanyan R, Vijay G, Nichol GS, et al. (2009) Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain. Bioorganic & Medicinal Chemistry. 17: 5044-53
Kumarasinghe IR, Hruby VJ, Nichol GS. (2009) 3-[1-(4-Sulfamoylphenyl)-5-p-tolyl-1H-pyrazol-3-yl]propanoic acid and 3-[5-(4-bromophenyl)-1-(4-sulfamoylphenyl)-1H-pyrazol-3-yl]propanoic acid-dichloromethane-diethyl ether-water (2/0.72/1/1). Acta Crystallographica. Section C, Crystal Structure Communications. 65: o296-9
Kumarasinghe IR, Hruby VJ, Nichol GS. (2009) 3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]propionic acid and the corresponding methyl ester. Acta Crystallographica. Section C, Crystal Structure Communications. 65: o163-6
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