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James Cain, Ph.D.

Affiliations: 
2011 Chemistry University of Arizona, Tucson, AZ 
Area:
Organic Chemistry, Biochemistry, Chemical Biology and Medicinal Chemistry
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Victor J. Hruby grad student 2011 University of Arizona
 (Design, synthesis, and evaluation of new ligands for G Protein-Coupled Receptors (GPCRs) and kinases.)

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Publications

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Wang H, Cain JG, Uraco A, et al. (2020) Getting to a New Normal: Mandating That Patients Wear Masks as Hospitals Fully Reopen during the Coronavirus Pandemic: Comment. Anesthesiology
Vardanyan RS, Cain JP, Haghighi SM, et al. (2017) Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain. Journal of Heterocyclic Chemistry. 54: 1228-1235
Cain J, Laskin A, Kholghy MR, et al. (2014) Molecular characterization of organic content of soot along the centerline of a coflow diffusion flame. Physical Chemistry Chemical Physics : Pccp. 16: 25862-75
Podolsky AT, Sandweiss A, Hu J, et al. (2013) Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain. Life Sciences. 93: 1010-6
Guo D, Cain JP, O'Connell S, et al. (2012) Preformulation study of NSC-726796. Aaps Pharmscitech. 13: 661-73
Liu Y, Minofar B, Desyaterik Y, et al. (2011) Internal structure, hygroscopic and reactive properties of mixed sodium methanesulfonate-sodium chloride particles. Physical Chemistry Chemical Physics : Pccp. 13: 11846-57
Mayorov AV, Cai M, Palmer ES, et al. (2011) Cyclic lactam hybrid α-MSH/Agouti-related protein (AGRP) analogues with nanomolar range binding affinities at the human melanocortin receptors. Bioorganic & Medicinal Chemistry Letters. 21: 3099-102
Hruby VJ, Cai M, Cain J, et al. (2011) Design of novel melanocortin receptor ligands: multiple receptors, complex pharmacology, the challenge. European Journal of Pharmacology. 660: 88-93
Mayorov AV, Cai M, Palmer ES, et al. (2010) Solid-phase peptide head-to-side chain cyclodimerization: discovery of C(2)-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors. Peptides. 31: 1894-905
Guo D, Nichol GS, Cain JP, et al. (2009) 2-[N-(2,4-Difluoro-phen-yl)carbamo-yl]-3,4,5,6-tetra-fluoro-benzoic acid. Acta Crystallographica. Section E, Structure Reports Online. 65: o2644
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