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Laurie B. Schenkel, Ph.D.

Affiliations: 
2005 University of California, Berkeley, Berkeley, CA, United States 
Area:
chemical synthesis
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Jonathan A. Ellman grad student 2005 UC Berkeley
 (Design and application of chiral sulfinyl imine ligands and synthetic applications of N-sulfinyl metalloenamine-based diastereoselective reactions.)

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Publications

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Wigle TJ, Blackwell DJ, Schenkel LB, et al. (2020) Abstract 506: A bespoke screening platform to study mono(ADP-ribosylation) Cancer Research. 80: 506-506
Schenkel LB, DiMauro EF, Nguyen HN, et al. (2017) Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors. Bioorganic & Medicinal Chemistry Letters
Graceffa RF, Boezio AA, Able J, et al. (2017) Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust In Vivo Activity. Journal of Medicinal Chemistry
DiMauro EF, Altmann S, Berry LM, et al. (2016) Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors. Journal of Medicinal Chemistry
Geuns-Meyer S, Cee VJ, Deak HL, et al. (2015) Discovery of N-(4-(3-(2-Aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), A Highly Selective, Orally Bioavailable Inhibitor of Aurora Kinases with Activity against Multidrug-Resistant Cancer Cell Lines. Journal of Medicinal Chemistry
Yu V, Pistillo J, Archibeque I, et al. (2013) Differential selectivity of JAK2 inhibitors in enzymatic and cellular settings. Experimental Hematology. 41: 491-500
Nguyen HN, Cee VJ, Deak HL, et al. (2012) Synthesis of 4-substituted chlorophthalazines, dihydrobenzoazepinediones, 2-pyrazolylbenzoic acid, and 2-pyrazolylbenzohydrazide via 3-substituted 3-hydroxyisoindolin-1-ones. The Journal of Organic Chemistry. 77: 3887-906
Schenkel LB, Huang X, Cheng A, et al. (2011) Discovery of potent and highly selective thienopyridine Janus kinase 2 inhibitors. Journal of Medicinal Chemistry. 54: 8440-50
Peterson EA, Andrews PS, Be X, et al. (2011) Discovery of triazine-benzimidazoles as selective inhibitors of mTOR. Bioorganic & Medicinal Chemistry Letters. 21: 2064-70
Liu L, Yu V, Pistillo J, et al. (2011) New Insights on Assessing Intra-Family Selectivity for Jak2 Inhibitors Blood. 118: 5150-5150
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