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Tyler D. Baguley, Ph.D.

Affiliations: 
2014 Chemistry University of California, Berkeley, Berkeley, CA, United States 
Area:
chemical synthesis
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Jonathan A. Ellman grad student 2014 UC Berkeley
 (Fragment Based Identification of Phosphatase Inhibitors.)

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Ardestani A, Li S, Annamalai K, et al. (2019) Neratinib protects pancreatic beta cells in diabetes. Nature Communications. 10: 5015
Zhong L, Tran T, Baguley TD, et al. (2018) A Novel Inhibitor of iNOS Dimerization Protects Against Cytokine-Induced Rat β-cell Dysfunction. British Journal of Pharmacology
Tjin CC, Otley KD, Baguley TD, et al. (2017) Glutathione-Responsive Selenosulfide Prodrugs as a Platform Strategy for Potent and Selective Mechanism-Based Inhibition of Protein Tyrosine Phosphatases. Acs Central Science. 3: 1322-1328
Xu J, Hartley BJ, Kurup P, et al. (2016) Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models. Molecular Psychiatry
Xu J, Kurup P, Baguley TD, et al. (2015) Inhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice. Cellular and Molecular Life Sciences : Cmls
Xu J, Kurup P, Azkona G, et al. (2015) Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61 ) levels. Journal of Neurochemistry
Azkona G, Saavedra A, Aira Z, et al. (2015) STEP modulates nociception: evidences from genetic deletion and pharmacological inhibition. Pain
Baguley TD, Nairn AC, Lombroso PJ, et al. (2015) Synthesis of benzopentathiepin analogs and their evaluation as inhibitors of the phosphatase STEP. Bioorganic & Medicinal Chemistry Letters. 25: 1044-6
Xu J, Chatterjee M, Baguley TD, et al. (2014) Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease. Plos Biology. 12: e1001923
Baguley TD, Xu HC, Chatterjee M, et al. (2013) Substrate-based fragment identification for the development of selective, nonpeptidic inhibitors of striatal-enriched protein tyrosine phosphatase. Journal of Medicinal Chemistry. 56: 7636-50
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