Patrick J. O'Brien, Ph.D.

2000 Stanford University, Palo Alto, CA 
"Patrick O'Brien"
Mean distance: 8.67


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Daniel Herschlag grad student 2000 Stanford
 (Mechanism and catalytic promiscuity of E. coli alkaline phosphatase.)
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Admiraal SJ, Eyler DE, Baldwin MR, et al. (2019) Expansion of base excision repair compensates for a lack of DNA repair by oxidative dealkylation in budding yeast. The Journal of Biological Chemistry
Admiraal SJ, O'Brien PJ. (2017) Reactivity and Cross-Linking of 5'-Terminal Abasic Sites Within DNA. Chemical Research in Toxicology
Admiraal SJ, O'Brien PJ. (2015) Base excision repair enzymes protect abasic sites in duplex DNA from interstrand cross-links. Biochemistry. 54: 1849-57
Taylor EL, O'Brien PJ. (2015) Kinetic mechanism for the flipping and excision of 1,N(6)-ethenoadenine by AlkA. Biochemistry. 54: 898-908
Hedglin M, Zhang Y, O'Brien PJ. (2015) Probing the DNA structural requirements for facilitated diffusion. Biochemistry. 54: 557-66
Admiraal SJ, O'Brien PJ. (2013) DNA-N-glycosylases process novel O-glycosidic sites in DNA. Biochemistry. 52: 4066-74
Taylor MR, Conrad JA, Wahl D, et al. (2011) Kinetic mechanism of human DNA ligase I reveals magnesium-dependent changes in the rate-limiting step that compromise ligation efficiency. The Journal of Biological Chemistry. 286: 23054-62
Nikolova EN, Kim E, Wise AA, et al. (2011) Transient Hoogsteen base pairs in canonical duplex DNA. Nature. 470: 498-502
Admiraal SJ, O'Brien PJ. (2010) N-glycosyl bond formation catalyzed by human alkyladenine DNA glycosylase. Biochemistry. 49: 9024-6
O'Brien PJ, Hollfelder F. (2010) Hitting a moving target?--Understanding how conformational diversity impacts enzymatic catalysis. Current Opinion in Chemical Biology. 14: 634-5
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