Matthew G. Stanton, Ph.D.
Affiliations: | 2003 | University of North Carolina, Chapel Hill, Chapel Hill, NC |
Area:
total synthesis of biologically active and structurally novel natural productsGoogle:
"Matthew Stanton"Mean distance: 8.8 | S | N | B | C | P |
Parents
Sign in to add mentor| Michael T. Crimmins | grad student | 2003 | UNC Chapel Hill | |
| (The total synthesis of (-)-laulimalide and efforts toward the total synthesis of (+)-lasonolide A.) | ||||
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Publications
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| Methot JL, Hoffman DM, Witter DJ, et al. (2014) Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor. Acs Medicinal Chemistry Letters. 5: 340-5 |
| Sankaranarayanan S, Holahan MA, Colussi D, et al. (2009) First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates. The Journal of Pharmacology and Experimental Therapeutics. 328: 131-40 |
| Lee AY, Paweletz CP, Pollock RM, et al. (2008) Quantitative analysis of histone deacetylase-1 selective histone modifications by differential mass spectrometry. Journal of Proteome Research. 7: 5177-86 |
| Methot JL, Chakravarty PK, Chenard M, et al. (2008) Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). Bioorganic & Medicinal Chemistry Letters. 18: 973-8 |
| Hamblett CL, Methot JL, Mampreian DM, et al. (2007) The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 5300-9 |
| Stanton MG, Stauffer SR, Gregro AR, et al. (2007) Discovery of isonicotinamide derived beta-secretase inhibitors: in vivo reduction of beta-amyloid. Journal of Medicinal Chemistry. 50: 3431-3 |
| Crimmins MT, Stanton MG, Allwein SP. (2002) Asymmetric total synthesis of (-)-laulimalide: exploiting the asymmetric glycolate alkylation reaction. Journal of the American Chemical Society. 124: 5958-9 |