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Manasi P. Bhate, Ph.D.

Affiliations: 
2012 Chemistry Columbia University, New York, NY 
Area:
NMR Structural Studies of Membrane Proteins, Enzymes, Hydrogen Bonding Geometry, and Dynamics
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"Manasi Bhate"
Mean distance: 9.38
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Ann E. McDermott grad student 2012 Columbia
 (Mechanistic studies of ion binding and inactivation in the potassium channel KcsA by solid state NMR.)

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Publications

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Bhate MP, Lemmin T, Kuenze G, et al. (2018) Structure and function of the transmembrane domain of NsaS, an antibiotic sensing histidine kinase in S. aureus. Journal of the American Chemical Society
Xu Y, Bhate MP, McDermott AE. (2017) Transmembrane allosteric energetics characterization for strong coupling between proton and potassium ion binding in the KcsA channel. Proceedings of the National Academy of Sciences of the United States of America
Joh NH, Wang T, Bhate MP, et al. (2014) De novo design of a transmembrane Zn²⁺-transporting four-helix bundle. Science (New York, N.Y.). 346: 1520-4
Wylie BJ, Bhate MP, McDermott AE. (2014) Transmembrane allosteric coupling of the gates in a potassium channel Proceedings of the National Academy of Sciences of the United States of America. 111: 185-190
Bhate MP, Wylie BJ, Thompson A, et al. (2013) Preparation of uniformly isotope labeled KcsA for solid state NMR: Expression, purification, reconstitution into liposomes and functional assay Protein Expression and Purification. 91: 119-124
Yamada T, Bhate MP, Strange K. (2013) Regulatory phosphorylation induces extracellular conformational changes in a CLC anion channel. Biophysical Journal. 104: 1893-904
Bhate MP, McDermott AE. (2012) Protonation state of E71 in KcsA and its role for channel collapse and inactivation Proceedings of the National Academy of Sciences of the United States of America. 109: 15265-15270
Bhate MP, Wylie BJ, Tian L, et al. (2010) Conformational dynamics in the selectivity filter of KcsA in response to potassium ion concentration Journal of Molecular Biology. 401: 155-166
Bhate M, Wylie B, Tian L, et al. (2010) [K+] Induced Conformational Dynamics of the Selectivity Filter of KcsA Monitored by Solid-State NMR Biophysical Journal. 98: 331a
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