Daniel M. Rosenbaum, Ph.D.

Affiliations: 
2005 Harvard University, Cambridge, MA, United States 
Area:
The Chemistry of Molecular Evolution
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Parents

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David R. Liu grad student 2005 Harvard
 (Directed evolution of functional synthetic and biological macromolecules.)
Brian K. Kobilka post-doc Stanford
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Publications

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Kumari P, Dvorácskó S, Enos MD, et al. (2024) Structural mechanism of CBR binding to peripheral and biased inverse agonists. Nature Communications. 15: 10694
Wang W, Ranjan A, Zhang W, et al. (2024) Novel orexin receptor agonists based on arene- or pyridine-fused 1,3-dihydro-2H-imidazole-2-imines. Bioorganic & Medicinal Chemistry Letters. 99: 129624
Yin J, Kang Y, McGrath AP, et al. (2023) Reply to: The G protein preference of orexin receptors is currently an unresolved issue. Nature Communications. 14: 3163
Kumari P, Inoue A, Chapman K, et al. (2023) Molecular mechanism of fatty acid activation of FFAR1. Proceedings of the National Academy of Sciences of the United States of America. 120: e2219569120
Yin J, Kang Y, McGrath AP, et al. (2022) Molecular mechanism of the wake-promoting agent TAK-925. Nature Communications. 13: 2902
Ramesh K, Rosenbaum DM. (2021) Molecular basis for ligand modulation of the cannabinoid receptor CB1. British Journal of Pharmacology
Ramesh K, Rosenbaum DM. (2021) Molecular basis for ligand modulation of the cannabinoid receptor CB1. British Journal of Pharmacology
Kober DL, Radhakrishnan A, Goldstein JL, et al. (2021) Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing. Cell
Xiao P, Yan W, Gou L, et al. (2021) Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell
Gunera J, Baker JG, van Hilten N, et al. (2020) Structure-Based Discovery of Novel Ligands for the Orexin 2 Receptor. Journal of Medicinal Chemistry
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