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Vikram Pattanayak, Ph.D.

Affiliations: 
2011 Harvard University, Cambridge, MA, United States 
Area:
The Chemistry of Molecular Evolution
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"Vikram Pattanayak"
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David R. Liu grad student 2011 Harvard
 (Revealing the DNA Cleavage Specificities of Therapeutically Relevant Endonucleases Through In Vitro Selection.)

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Publications

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Garrood WT, Kranjc N, Petri K, et al. (2021) Analysis of off-target effects in CRISPR-based gene drives in the human malaria mosquito. Proceedings of the National Academy of Sciences of the United States of America. 118
Kleinstiver BP, Pattanayak V, Prew MS, et al. (2016) High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects. Nature
Kleinstiver BP, Pattanayak V, Prew MS, et al. (2016) 731. High-Fidelity CRISPR-Cas9 Nucleases with No Detectable Genome-Wide Off-Target Effects Molecular Therapy. 24
Davis KM, Pattanayak V, Thompson DB, et al. (2015) Small molecule-triggered Cas9 protein with improved genome-editing specificity. Nature Chemical Biology. 11: 316-8
Pattanayak V, Guilinger JP, Liu DR. (2014) Determining the specificities of TALENs, Cas9, and other genome-editing enzymes. Methods in Enzymology. 546: 47-78
Guilinger JP, Pattanayak V, Reyon D, et al. (2014) Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity Nature Methods. 11: 429-435
Pattanayak V, Guilinger JP, Liu DR. (2014) Determining the specificities of TALENs, cas9, and other genome-editing enzymes Methods in Enzymology. 546: 47-78
Sander JD, Ramirez CL, Linder SJ, et al. (2013) In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites. Nucleic Acids Research. 41: e181
Pattanayak V, Lin S, Guilinger JP, et al. (2013) High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity. Nature Biotechnology. 31: 839-43
Pattanayak V, Ramirez CL, Joung JK, et al. (2011) Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection. Nature Methods. 8: 765-70
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