Hongbing Huang, Ph.D.
Affiliations: | 2005 | Boston University, Boston, MA, United States |
Area:
synthetic organic chemistryGoogle:
"Hongbing Huang"Mean distance: 8.6 | S | N | B | C | P |
Parents
Sign in to add mentor| James S. Panek | grad student | 2005 | Boston University | |
| (Enantioselective synthesis of functionalized dihydropyrans and tetrahydropyridines: Application to the synthesis of quinolizidine (-)-217A and callipeltoside A.) | ||||
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Publications
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| Boezio AA, Andrews K, Boezio C, et al. (2018) 1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of Na1.7 inhibition. Bioorganic & Medicinal Chemistry Letters |
| Graceffa RF, Boezio AA, Able J, et al. (2017) Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust In Vivo Activity. Journal of Medicinal Chemistry |
| Weiss MM, Dineen TA, Marx IE, et al. (2017) Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities. Journal of Medicinal Chemistry |
| DiMauro EF, Altmann S, Berry LM, et al. (2016) Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors. Journal of Medicinal Chemistry |
| Ablikim M, Achasov MN, Ai XC, et al. (2015) Observation of a Neutral Charmoniumlike State Z_{c}(4025)^{0} in e^{+}e^{-}→(D^{*}D[over ¯]^{*})^{0}π^{0}. Physical Review Letters. 115: 182002 |
| Huang H, Acquaviva L, Berry V, et al. (2012) Structure-Based Design of Potent and Selective CK1γ Inhibitors. Acs Medicinal Chemistry Letters. 3: 1059-64 |
| Huang H, La DS, Cheng AC, et al. (2012) Structure- and property-based design of aminooxazoline xanthenes as selective, orally efficacious, and CNS penetrable BACE inhibitors for the treatment of Alzheimer's disease. Journal of Medicinal Chemistry. 55: 9156-69 |
| Dineen TA, Weiss MM, Williamson T, et al. (2012) Design and synthesis of potent, orally efficacious hydroxyethylamine derived β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors. Journal of Medicinal Chemistry. 55: 9025-44 |
| Huang H, Panek JS. (2004) Total synthesis of callipeltoside A Organic Letters. 6: 4383-4385 |
| Huang H, Panek JS. (2003) Organosilanes in synthesis: Application to an enantioselective synthesis of methyl-L-callipeltose Organic Letters. 5: 1991-1993 |