Jason T. Lowe, Ph.D.

Affiliations: 
2009 Boston University, Boston, MA, United States 
Area:
synthetic organic chemistry
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Parents

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William M Rosen grad student 1995 University of Rhode Island
James S. Panek grad student 2009 Boston University
 (Total syntheses of bistramide A and (-)-kendomycin.)
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Publications

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Arai K, Buonamici S, Chan B, et al. (2014) Total synthesis of 6-deoxypladienolide D and Assessment of Splicing Inhibitory Activity in a Mutant SF3B1 cancer cell line. Organic Letters. 16: 5560-3
Gerard B, Lee MD, Dandapani S, et al. (2013) Synthesis of stereochemically and skeletally diverse fused ring systems from functionalized C-glycosides. The Journal of Organic Chemistry. 78: 5160-71
Lowe JT, Lee MD, Akella LB, et al. (2012) Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries. The Journal of Organic Chemistry. 77: 7187-211
Dandapani S, Lowe JT, Comer E, et al. (2011) Diversity-oriented synthesis of 13- to 18-membered macrolactams via ring-closing metathesis. The Journal of Organic Chemistry. 76: 8042-8
Gerard B, Duvall JR, Lowe JT, et al. (2011) Synthesis of a stereochemically diverse library of medium-sized lactams and sultams via S(N)Ar cycloetherification. Acs Combinatorial Science. 13: 365-74
Marcaurelle LA, Comer E, Dandapani S, et al. (2010) An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors. Journal of the American Chemical Society. 132: 16962-76
Brawn RA, Welzel M, Lowe JT, et al. (2010) Regioselective intramolecular dipolar cycloaddition of azides and unsymmetrical alkynes Organic Letters. 12: 336-339
Wrona IE, Lowe JT, Turbyville TJ, et al. (2009) Synthesis of a 35-member stereoisomer library of bistramide A: evaluation of effects on actin state, cell cycle and tumor cell growth. The Journal of Organic Chemistry. 74: 1897-916
Lowe JT, Panek JS. (2008) Total synthesis of (-)-kendomycin Organic Letters. 10: 3813-3816
Youngsaye W, Lowe JT, Pohlki F, et al. (2007) Total synthesis and stereochemical reassignment of (+)-neopeltolide Angewandte Chemie - International Edition. 46: 9211-9214
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