Kristin J. Labby, Ph.D.
Affiliations: | 2012 | Chemistry | Northwestern University, Evanston, IL |
Area:
Organic, Synthetic, Bio-Organic, Medicinal Chemistry, Chemical BiologyGoogle:
"Kristin Labby"Mean distance: 9.2 | S | N | B | C | P |
Parents
Sign in to add mentor| Richard B. Silverman | grad student | 2012 | Northwestern | |
| (Nitric Oxide Synthase -- Assays, Membrane-Permeable Inhibitors, and Substrate Analogues as Mechanistic Probes.) | ||||
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Publications
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| Won SJ, Davda D, Labby KJ, et al. (2016) Molecular mechanism for isoform-selective inhibition of acyl protein thioesterases 1 and 2 (APT1 and APT2). Acs Chemical Biology |
| Majmudar JD, Konopko AM, Labby KJ, et al. (2016) Harnessing redox cross-reactivity to profile distinct cysteine modifications. Journal of the American Chemical Society |
| Davydov R, Labby KJ, Chobot SE, et al. (2014) Enzymatic and cryoreduction EPR studies of the hydroxylation of methylated N(ω)-hydroxy-L-arginine analogues by nitric oxide synthase from Geobacillus stearothermophilus. Biochemistry. 53: 6511-9 |
| Labby KJ, Garneau-Tsodikova S. (2013) Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections. Future Medicinal Chemistry. 5: 1285-309 |
| Berkov-Zrihen Y, Green KD, Labby KJ, et al. (2013) Synthesis and evaluation of hetero- and homodimers of ribosome-targeting antibiotics: antimicrobial activity, in vitro inhibition of translation, and drug resistance. Journal of Medicinal Chemistry. 56: 5613-25 |
| Labby KJ, Li H, Roman LJ, et al. (2013) Methylated Nω-hydroxy-l-arginine analogues as mechanistic probes for the second step of the nitric oxide synthase-catalyzed reaction Biochemistry. 52: 3062-3073 |
| Li H, Xue F, Kraus JM, et al. (2013) Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase Bioorganic and Medicinal Chemistry. 21: 1333-1343 |
| Huang H, Ji H, Li H, et al. (2012) Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations. Journal of the American Chemical Society. 134: 11559-72 |
| Labby KJ, Xue F, Kraus JM, et al. (2012) Intramolecular hydrogen bonding: A potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase Bioorganic and Medicinal Chemistry. 20: 2435-2443 |
| Xue F, Kraus JM, Labby KJ, et al. (2011) Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase Journal of Medicinal Chemistry. 54: 6399-6403 |