Paul M. Wehn, Ph.D.

Affiliations: 
2006 Stanford University, Palo Alto, CA 
Area:
Organic, Inorganic and Biological Chemistry
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"Paul Wehn"
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Justin Du Bois grad student 2006 Stanford
 (The development and application of rhodium-catalyzed carbon-hydrogen amination reactions in the synthesis of bromopyrrole alkaloids: Enantioselective synthesis of (-)-manzacidin A, (+)-manzacidin C, and (-)-agelastatin A.)
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Li Z, Wang X, Eksterowicz J, et al. (2014) Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3. Journal of Medicinal Chemistry. 57: 3430-49
Wehn PM, Harrington PE, Carlson TJ, et al. (2013) Metabolism-guided discovery of a potent and orally bioavailable urea-based calcimimetic for the treatment of secondary hyperparathyroidism. Bioorganic & Medicinal Chemistry Letters. 23: 6625-8
Wehn PM, Du Bois J. (2009) A stereoselective synthesis of the bromopyrrole natural product (-)-agelastatin A. Angewandte Chemie (International Ed. in English). 48: 3802-5
Guthikonda K, Wehn PM, Caliando BJ, et al. (2006) Rh-catalyzed alkene oxidation: a highly efficient and selective process for preparing N-alkoxysulfonyl aziridines Tetrahedron. 62: 11331-11342
Wehn PM, Du Bois J. (2005) Exploring new uses for C-H amination: Ni-catalyzed cross-coupling of cyclic sulfamates Organic Letters. 7: 4685-4688
Wehn PM, Lee J, Du Bois J. (2003) Stereochemical Models for Rh-Catalyzed Amination Reactions of Chiral Sulfamates Organic Letters. 5: 4823-4826
Wehn PM, Du Bois J. (2002) Enantioselective synthesis of the bromopyrrole alkaloids manzacidin A and C by stereospecific C-H bond oxidation Journal of the American Chemical Society. 124: 12950-12951
Espino CG, Wehn PM, Chow J, et al. (2001) Synthesis of 1,3-difunctionalized amine derivatives through selective C-H bond oxidation Journal of the American Chemical Society. 123: 6935-6936
Moreira RF, Wehn PM, Sames D. (2000) Highly Regioselective Oxygenation of C-H Bonds: Diamidomanganese Constructs with Attached Substrates as Catalyst Models Financial support has been provided by Columbia University and the Camille and Henry Dreyfus Foundation. P.M.W. acknowledges the REU-NSF program for summer support. We also thank Dr. J. B. Schwarz (manuscript preparation) and Dr. Y. Itagaki (mass spectrometry). Angewandte Chemie (International Ed. in English). 39: 1618-1621
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