Matthew G. LaPorte, Ph.D.

Affiliations: 
2000 Pennsylvania State University, State College, PA, United States 
Area:
Total Synthesis of Natural Products
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Steven M. Weinreb grad student 2000 Penn State
 (The development of an amide oxidation method and the enantioselective total synthesis of the Securinega alkaloid (-)-phyllanthine.)
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Publications

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LaPorte MG, Wang Z, Colombo R, et al. (2016) Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors. Bioorganic & Medicinal Chemistry Letters
Deng Y, Haimowitz T, LaPorte MG, et al. (2016) Electrophilic Oxidation and [1,2]-Rearrangement of the Biindole Core of Birinapant. Acs Medicinal Chemistry Letters. 7: 318-23
Alverez C, Bulfer SL, Chakrasali R, et al. (2016) Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway Acs Medicinal Chemistry Letters. 7: 182-187
Deng Y, Xie Q, LaPorte MG, et al. (2016) Process Development and Synthesis of Birinapant: Large Scale Preparation and Acid-Mediated Dimerization of the Key Indole Intermediate Organic Process Research and Development. 20: 242-252
Johnston PA, Sen M, Hua Y, et al. (2015) HCS Campaign to Identify Selective Inhibitors of IL-6-Induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines. Assay and Drug Development Technologies. 13: 356-76
Alverez C, Arkin MR, Bulfer SL, et al. (2015) Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97 Acs Medicinal Chemistry Letters. 6: 1225-1230
LaPorte MG, da Paz Lima DJ, Zhang F, et al. (2014) 2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway. Bioorganic & Medicinal Chemistry Letters. 24: 5081-5
Condon SM, Mitsuuchi Y, Deng Y, et al. (2014) Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies. Journal of Medicinal Chemistry. 57: 3666-77
Benetatos CA, Mitsuuchi Y, Burns JM, et al. (2014) Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft models. Molecular Cancer Therapeutics. 13: 867-79
Zhang H, Jeon KO, Hay EB, et al. (2014) Radical [3 + 2]-annulation of divinylcyclopropanes: rapid synthesis of complex meloscine analogs. Organic Letters. 16: 94-7
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