Neil J. Lajkiewicz, Ph.D.

Affiliations: 
2015 Chemistry Boston University, Boston, MA, United States 
Area:
synthesis of complex natural products
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John A. Porco grad student 2015 Boston University
 (Synthesis of aglain natural products and synthetic rocaglate derivatives.)
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Publications

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Porco J, Wang W, Clay A, et al. (2017) Total Syntheses of the Isomeric Aglain Natural Products Foveoglin A and Perviridisin B via Selective ESIPT Photocycloaddition. Angewandte Chemie (International Ed. in English)
Liu S, Wang W, Brown LE, et al. (2015) A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway. Ebiomedicine. 2: 1600-6
Stone SD, Lajkiewicz NJ, Whitesell L, et al. (2015) Biomimetic kinetic resolution: highly enantio- and diastereoselective transfer hydrogenation of aglain ketones to access flavagline natural products. Journal of the American Chemical Society. 137: 525-30
Liu S, Wang W, Brown LE, et al. (2015) A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway Ebiomedicine
Lajkiewicz NJ, Cognetta AB, Niphakis MJ, et al. (2014) Remodeling natural products: chemistry and serine hydrolase activity of a rocaglate-derived β-lactone. Journal of the American Chemical Society. 136: 2659-64
Lajkiewicz NJ, Roche SP, Gerard B, et al. (2012) Enantioselective photocycloaddition of 3-hydroxyflavones: total syntheses and absolute configuration assignments of (+)-ponapensin and (+)-elliptifoline. Journal of the American Chemical Society. 134: 13108-13
Ebada SS, Lajkiewicz N, Porco JA, et al. (2011) Chemistry and biology of rocaglamides (= flavaglines) and related derivatives from aglaia species (meliaceae). Progress in the Chemistry of Organic Natural Products. 94: 1-58
Burgess KL, Corbett MS, Eugenio P, et al. (2005) Chiral anthracene and anthrone templates as stereocontrolling elements in Diels-Alder/retro Diels-Alder sequences. Bioorganic & Medicinal Chemistry. 13: 5299-309
Burgess KL, Lajkiewicz NJ, Sanyal A, et al. (2005) A new chiral anthracene for the asymmetric Diels-Alder/retro-Diels-Alder sequence. Organic Letters. 7: 31-4
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