Liangcai Gu, Ph.D.

Affiliations: 
2008 University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
cryptophycin anticancer drugs
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"Liangcai Gu"
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Parents

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David H. Sherman grad student 2008 University of Michigan
 (Biosynthetic innovation on a polyketide assembly line: Biochemical studies of curacin A pathway.)

Children

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Jonathan Cheng research scientist 2015-2018 University of Washington (Neurotree)
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Publications

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Khare D, Hale WA, Tripathi A, et al. (2015) Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase. Structure (London, England : 1993)
Liu B, Xue Y, Zhao W, et al. (2015) Three-dimensional super-resolution protein localization correlated with vitrified cellular context. Scientific Reports. 5: 13017
Li J, Gu L, Aach J, et al. (2014) Improved cell-free RNA and protein synthesis system. Plos One. 9: e106232
Gehret JJ, Gu L, Geders TW, et al. (2012) Structure and activity of DmmA, a marine haloalkane dehalogenase. Protein Science : a Publication of the Protein Society. 21: 239-48
Busche A, Gottstein D, Hein C, et al. (2012) Characterization of molecular interactions between ACP and halogenase domains in the Curacin A polyketide synthase. Acs Chemical Biology. 7: 378-86
Gu L, Eisman EB, Dutta S, et al. (2011) Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect. Angewandte Chemie (International Ed. in English). 50: 2795-8
Gehret JJ, Gu L, Gerwick WH, et al. (2011) Terminal alkene formation by the thioesterase of curacin A biosynthesis: structure of a decarboxylating thioesterase. The Journal of Biological Chemistry. 286: 14445-54
Khare D, Wang B, Gu L, et al. (2010) Conformational switch triggered by alpha-ketoglutarate in a halogenase of curacin A biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 14099-104
Gu L, Wang B, Kulkarni A, et al. (2009) Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis. Journal of the American Chemical Society. 131: 16033-5
Gu L, Wang B, Kulkarni A, et al. (2009) Metamorphic enzyme assembly in polyketide diversification. Nature. 459: 731-5
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