Shengying Li, Ph.D.

Affiliations: 
2009 University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
cryptophycin anticancer drugs
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David H. Sherman grad student 2009 University of Michigan
 (Biochemical, structural, and bioengineering studies of cytochrome P450 enzymes involved in biosynthesis of secondary metabolites.)
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Publications

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Zhang C, Zhou J, Wang W, et al. (2025) Oxidative Electrocyclization Assembles 2,2-Dimethyl-2H-pyran in Fungal Indole Alkaloids. Angewandte Chemie (International Ed. in English). e202506276
Jiang Y, Gong P, Li Z, et al. (2025) Unexpected Activities of CYP152 Peroxygenases towards Non-carboxylic Substrates Reveal Novel Substrate Recognition Mechanism and Catalytic Versatility. Angewandte Chemie (International Ed. in English). e202506614
Du L, Dian L, Newmister SA, et al. (2025) The Mutually Inspiring Biological and Chemical Synthesis of Fungal Bicyclo[2.2.2]diazaoctane Indole Alkaloids. Chemical Reviews
You C, Pan Y, Liu R, et al. (2024) Structural basis for substrate flexibility of the O-methyltransferase MpaG' involved in mycophenolic acid biosynthesis. Protein Science : a Publication of the Protein Society. 33: e5144
Xia Y, Zhu G, Zhang X, et al. (2023) Biosynthesis of 4-Acyl-5-aminoimidazole Alkaloids Featuring a New Friedel-Crafts Acyltransferase. Journal of the American Chemical Society
Li Z, Zhang L, Xu K, et al. (2023) Molecular insights into the catalytic promiscuity of a bacterial diterpene synthase. Nature Communications. 14: 4001
Pan Y, Li G, Liu R, et al. (2023) Unnatural activities and mechanistic insights of cytochrome P450 PikC gained from site-specific mutagenesis by non-canonical amino acids. Nature Communications. 14: 1669
Liu R, Pan Y, Wang N, et al. (2023) Comparative biochemical characterization of mammalian-derived CYP11A1s with cholesterol side-chain cleavage activities. The Journal of Steroid Biochemistry and Molecular Biology. 229: 106268
Jiang Y, Peng W, Li Z, et al. (2021) Unexpected Reactions of α,β-Unsaturated Fatty Acids Provide Insight into the Mechanisms of CYP152 Peroxygenases. Angewandte Chemie (International Ed. in English)
Zhang X, Xu X, You C, et al. (2021) Biosynthesis of chuangxinmycin featuring a deubiquitinase-like sulfurtransferase. Angewandte Chemie (International Ed. in English)
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