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Ohara Augusto, Ph.D.

Affiliations: 
1977- Departamento de Bioquímica University of São Paulo, São Paulo, São Paulo, Brazil 
Area:
Chemistry and Biochemistry of Free Radicals, Applications of Electronic Paramagnetic Resonance (EPR) in Biomedicine, Biological Oxidations, Redox Equilibrium in cells and organisms, Nitric Oxide and derived oxidants
Website:
http://www.iq.usp.br/oaugusto/indexing.html
Google:
"Ohara Augusto"
Bio:

She entered the Chemistry undergraduate program of the Chemical Institute of the University of São Paulo, IQ/USP, in 1967. She was however, only an average student during the course. Times were troubled, the course structure was very rigid and there were financial difficulties. These factors led her to teach Chemistry at the high school level during the night period (1969/1971) instead of researching in the Institute's laboratories. Once she earned her Bachelor's degree, she still believed her calling was to do scientific research, so she chose graduate school. She knew very little about the work being developed at the Institute, but was lucky to be a personal friend of Prof. Francisco G. Nóbrega, who advised her look for Prof. Giuseppe Cilento.
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Mean distance: 8.27
 
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Parents

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Giuseppe Cilento grad student 1972-1975 USP
 (Ph.D. student)
Lester Packer post-doc 1979-1980 UC Berkeley
Paul R. Ortiz de Montellano post-doc 1980-1982 UCSF
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Publications

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Gonçalves LCP, Massari J, Licciardi S, et al. (2020) Singlet oxygen generation by the reaction of acrolein with peroxynitrite via a 2-hydroxyvinyl radical intermediate. Free Radical Biology & Medicine. 152: 83-90
Weller CE, Dhall A, Ding F, et al. (2016) Aromatic thiol-mediated cleavage of N-O bonds enables chemical ubiquitylation of folded proteins. Nature Communications. 7: 12979
Tairum CA, Santos MC, Breyer CA, et al. (2016) Catalytic Thr or Ser Residue Modulates Structural Switches in 2-Cys Peroxiredoxin by Distinct Mechanisms. Scientific Reports. 6: 33133
Forman HJ, Augusto O, Brigelius-Flohe R, et al. (2015) Even free radicals should follow some rules: a guide to free radical research terminology and methodology. Free Radical Biology & Medicine. 78: 233-5
Linares E, Seixas LV, dos Prazeres JN, et al. (2013) Tempol moderately extends survival in a hSOD1(G93A) ALS rat model by inhibiting neuronal cell loss, oxidative damage and levels of non-native hSOD1(G93A) forms. Plos One. 8: e55868
Queliconi BB, Marazzi TB, Vaz SM, et al. (2013) Bicarbonate modulates oxidative and functional damage in ischemia-reperfusion. Free Radical Biology & Medicine. 55: 46-53
Toledo JC, Audi R, Ogusucu R, et al. (2011) Horseradish peroxidase compound I as a tool to investigate reactive protein-cysteine residues: from quantification to kinetics. Free Radical Biology & Medicine. 50: 1032-8
Busso C, Tahara EB, Ogusucu R, et al. (2010) Saccharomyces cerevisiae coq10 null mutants are responsive to antimycin A Febs Journal. 277: 4530-4538
Guerreiro JR, Lameu C, Oliveira EF, et al. (2009) Argininosuccinate synthetase is a functional target for a snake venom anti-hypertensive peptide: role in arginine and nitric oxide production. The Journal of Biological Chemistry. 284: 20022-33
Arai RJ, Ogata FT, Batista WL, et al. (2008) Thioredoxin-1 promotes survival in cells exposed to S-nitrosoglutathione: Correlation with reduction of intracellular levels of nitrosothiols and up-regulation of the ERK1/2 MAP Kinases. Toxicology and Applied Pharmacology. 233: 227-37
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