Joshua S. Grimley, Ph.D.

Affiliations: 
2007 Stanford University, Palo Alto, CA 
Area:
biological chemistry
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"Joshua Grimley"
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Thomas J. Wandless grad student 2007 Stanford
 (The synthesis of FKBP ligands and the first total synthesis of phomopsin B.)
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Publications

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Martinez RA, Stein JL, Krostag AR, et al. (2015) Genome engineering of isogenic human ES cells to model autism disorders. Nucleic Acids Research. 43: e65
Grimley JS, Li L, Wang W, et al. (2013) Visualization of synaptic inhibition with an optogenetic sensor developed by cell-free protein engineering automation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 16297-309
Alvarez JV, Pan Tc, Ruth J, et al. (2013) Par-4 Downregulation Promotes Breast Cancer Recurrence by Preventing Multinucleation following Targeted Therapy Cancer Cell. 24: 30-44
Dvorin JD, Martyn DC, Patel SD, et al. (2010) A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science (New York, N.Y.). 328: 910-2
Grimley JS, Chen DA, Banaszynski LA, et al. (2008) Synthesis and analysis of stabilizing ligands for FKBP-derived destabilizing domains Bioorganic and Medicinal Chemistry Letters. 18: 759-761
Herm-Götz A, Agop-Nersesian C, Münter S, et al. (2007) Rapid control of protein level in the apicomplexan Toxoplasma gondii Nature Methods. 4: 1003-1005
Grimley JS, Sawayama AM, Tanaka H, et al. (2007) The enantioselective synthesis of phomopsin B Angewandte Chemie - International Edition. 46: 8157-8159
Bayle JH, Grimley JS, Stankunas K, et al. (2006) Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity. Chemistry & Biology. 13: 99-107
Inoue T, Heo WD, Grimley JS, et al. (2005) An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways Nature Methods. 2: 415-418
Martin MB, Sanders JM, Kendrick H, et al. (2002) Activity of bisphosphonates against Trypanosoma brucei rhodesiense. Journal of Medicinal Chemistry. 45: 2904-14
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