Kevin P. McCusker, Ph.D.
Affiliations: | 2009 | University of California, Berkeley, Berkeley, CA, United States |
Area:
fundamental aspects of enzyme catalysisGoogle:
"Kevin McCusker"Mean distance: 8.54 | S | N | B | C | P |
Parents
Sign in to add mentorJudith Pollock Klinman | grad student | 2009 | UC Berkeley | |
(Mechanisms of oxygen activation and coupling to carbon-hydrogen cleavage in taurine alpha-ketoglutarate dioxygenase (TauD) and active-site mutants.) | ||||
Danica G. Fujimori | post-doc | 2010- | UCSF |
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Publications
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McCusker KP, Medzihradszky KF, Shiver AL, et al. (2012) Covalent intermediate in the catalytic mechanism of the radical S-adenosyl-L-methionine methyl synthase RlmN trapped by mutagenesis. Journal of the American Chemical Society. 134: 18074-81 |
McCusker KP, Fujimori DG. (2012) The chemistry of peptidyltransferase center-targeted antibiotics: enzymatic resistance and approaches to countering resistance. Acs Chemical Biology. 7: 64-72 |
McCusker KP, Klinman JP. (2010) An active-site phenylalanine directs substrate binding and C-H cleavage in the α-ketoglutarate-dependent dioxygenase AauD Journal of the American Chemical Society. 132: 5114-5120 |
McCusker KP, Klinman JP. (2009) Modular behavior of tauD provides insight into the origin of specificity in α-ketoglutarate-dependent nonheme iron oxygenases Proceedings of the National Academy of Sciences of the United States of America. 106: 19791-19795 |
McCusker KP, Klinman JP. (2009) Facile synthesis of 1,1-[2H2]-2-methylaminoethane-1-sulfonic acid as a substrate for taurine α ketoglutarate dioxygenase (TauD) Tetrahedron Letters. 50: 611-613 |
Mirica LM, McCusker KP, Munos JW, et al. (2008) 18O kinetic isotope effects in non-heme iron enzymes: probing the nature of Fe/O2 intermediates. Journal of the American Chemical Society. 130: 8122-3 |
Thrower J, Mirica LM, McCusker KP, et al. (2006) Mechanistic investigations of 1-aminocyclopropane 1-carboxylic acid oxidase with alternate cyclic and acyclic substrates. Biochemistry. 45: 13108-17 |