Joseph D. Ho, Ph.D.

Affiliations: 
2009 Chemistry and Chemical Biology University of California, San Francisco, San Francisco, CA 
Area:
membrane protein characterizations and crystal structures
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"Joseph Ho"
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Robert M. Stroud grad student 2009 UCSF
 (Heterologous expression of human membrane protein drug targets and the X-ray crystallographic determination of the human aquaporin 4 structure.)
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Publications

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Nelson PA, Khodadoust M, Prodhomme T, et al. (2010) Immunodominant T cell determinants of aquaporin-4, the autoantigen associated with neuromyelitis optica. Plos One. 5: e15050
Gruswitz F, Chaudhary S, Ho JD, et al. (2010) Function of human Rh based on structure of RhCG at 2.1 A. Proceedings of the National Academy of Sciences of the United States of America. 107: 9638-43
Ho JD, Yeh R, Sandstrom A, et al. (2009) Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance. Proceedings of the National Academy of Sciences of the United States of America. 106: 7437-42
Newby ZE, O'Connell JD, Gruswitz F, et al. (2009) A general protocol for the crystallization of membrane proteins for X-ray structural investigation. Nature Protocols. 4: 619-37
Pan H, Ho JD, Stroud RM, et al. (2007) The crystal structure of E. coli rRNA pseudouridine synthase RluE. Journal of Molecular Biology. 367: 1459-70
McGrath ME, Sprengeler PA, Hirschbein B, et al. (2006) Structure-guided design of peptide-based tryptase inhibitors. Biochemistry. 45: 5964-73
Wang JC, Shah N, Pantoja C, et al. (2006) Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity Genes and Development. 20: 689-699
Katz BA, Luong C, Ho JD, et al. (2004) Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA). Journal of Molecular Biology. 344: 527-47
Somoza JR, Skene RJ, Katz BA, et al. (2004) Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases. Structure (London, England : 1993). 12: 1325-34
Somoza JR, Ho JD, Luong C, et al. (2003) The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain. Structure (London, England : 1993). 11: 1123-31
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