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Justin Blethrow, Ph.D.

Affiliations: 
2007 Chemistry and Chemical Biology University of California, San Francisco, San Francisco, CA 
Area:
signal transduction pathways in cells and whole organisms
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"Justin Blethrow"
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Kevan Michael Shokat grad student 2002-2007 UCSF
 (Covalent capture of kinase substrate phosphopeptides for analysis of cellular signaling networks.)

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Publications

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Blethrow JD, DiGuilio AL, Glavy JS. (2022) Purification of Cdk-CyclinB-Kinase-Targeted Phosphopeptides from Nuclear Envelope. Methods in Molecular Biology (Clifton, N.J.). 2502: 271-282
Li S, Makovets S, Matsuguchi T, et al. (2009) Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression. Cell. 136: 50-61
Kim HH, Abdelmohsen K, Lal A, et al. (2008) Nuclear HuR accumulation through phosphorylation by Cdk1. Genes & Development. 22: 1804-15
Blethrow JD, Glavy JS, Morgan DO, et al. (2008) Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates. Proceedings of the National Academy of Sciences of the United States of America. 105: 1442-7
Larochelle S, Batliner J, Gamble MJ, et al. (2006) Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics. Nature Structural & Molecular Biology. 13: 55-62
Dephoure N, Howson RW, Blethrow JD, et al. (2005) Combining chemical genetics and proteomics to identify protein kinase substrates. Proceedings of the National Academy of Sciences of the United States of America. 102: 17940-5
Blethrow J, Zhang C, Shokat KM, et al. (2004) Design and use of analog-sensitive protein kinases. Current Protocols in Molecular Biology. Unit 18.11
Ubersax JA, Woodbury EL, Quang PN, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature. 425: 859-64
Kraybill BC, Elkin LL, Blethrow JD, et al. (2002) Inhibitor scaffolds as new allele specific kinase substrates. Journal of the American Chemical Society. 124: 12118-28
Polson AG, Huang L, Lukac DM, et al. (2001) Kaposi's sarcoma-associated herpesvirus K-bZIP protein is phosphorylated by cyclin-dependent kinases. Journal of Virology. 75: 3175-84
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