Matthew L. Kutys, Ph.D.

Affiliations: 
2014 Cell and Developmental Biology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Cytoskeleton, Focal Adhesions
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Keith Burridge grad student 2014 UNC Chapel Hill
 (A novel, matrix-specific GEF/GAP interaction regulates Rho GTPase crosstalk critical for 3D collagen migration.)
Kenneth Yamada grad student 2014 UNC Chapel Hill
 (A novel, matrix-specific GEF/GAP interaction regulates Rho GTPase crosstalk critical for 3D collagen migration.)
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Publications

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White MJ, Jacobs KA, Singh T, et al. (2023) Notch1 cortical signaling regulates epithelial architecture and cell-cell adhesion. The Journal of Cell Biology. 222
Lee E, Chan SL, Lee Y, et al. (2023) A 3D biomimetic model of lymphatics reveals cell-cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex. Proceedings of the National Academy of Sciences of the United States of America. 120: e2308941120
Aw WY, Cho C, Wang H, et al. (2023) Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation. Science Advances. 9: eade8939
White MJ, Jacobs KA, Singh T, et al. (2023) Notch1 cortical signaling regulates epithelial architecture and cell-cell adhesion. Biorxiv : the Preprint Server For Biology
Doyle AD, Sykora DJ, Pacheco GG, et al. (2021) 3D mesenchymal cell migration is driven by anterior cellular contraction that generates an extracellular matrix prestrain. Developmental Cell
Kutys ML, Polacheck WJ, Welch MK, et al. (2020) Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform. Nature Communications. 11: 3377
Polacheck WJ, Kutys ML, Tefft JB, et al. (2019) Microfabricated blood vessels for modeling the vascular transport barrier. Nature Protocols
Wang WY, Pearson AT, Kutys ML, et al. (2018) Extracellular matrix alignment dictates the organization of focal adhesions and directs uniaxial cell migration. Apl Bioengineering. 2: 046107
Chopra A, Kutys ML, Zhang K, et al. (2018) Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions. Developmental Cell. 44: 87-96.e5
Polacheck WJ, Kutys ML, Yang J, et al. (2017) A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Nature
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