Melissa A. Mefford, Ph.D.

2009 University of Chicago, Chicago, IL 
mRNA processing
"Melissa Mefford"
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Jon Staley grad student 2009 Chicago
 (snRNA structure and dynamics during the catalytic phase of pre -mRNA splicing.)
David C. Zappulla grad student 2016 Johns Hopkins (Telomere and Telomerase Tree)
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Mefford MA, Hass EP, Zappulla DC. (2020) A 4-base pair core-enclosing helix in telomerase RNA is essential for activity and for binding to the TERT catalytic protein subunit. Molecular and Cellular Biology
Mefford MA, Zappulla DC. (2015) Physical connectivity mapping by circular permutation of human telomerase RNA reveals new regions critical for activity and processivity. Molecular and Cellular Biology
Fica SM, Mefford MA, Piccirilli JA, et al. (2014) Evidence for a group II intron-like catalytic triplex in the spliceosome. Nature Structural & Molecular Biology. 21: 464-71
Mefford MA, Rafiq Q, Zappulla DC. (2013) RNA connectivity requirements between conserved elements in the core of the yeast telomerase RNP. The Embo Journal. 32: 2980-93
Mefford MA, Staley JP. (2009) Evidence that U2/U6 helix I promotes both catalytic steps of pre-mRNA splicing and rearranges in between these steps. Rna (New York, N.Y.). 15: 1386-97
Hilliker AK, Mefford MA, Staley JP. (2007) U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicing. Genes & Development. 21: 821-34
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